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Efficacy and tolerability of anticholinergics in Korean children with overactive bladder: a multicenter retrospective study.

Authors
 Se Jin Park  ;  Ki Soo Pai  ;  Jun Mo Kim  ;  Kwanjin Park  ;  Kun Suk Kim  ;  Sang Hoon Song  ;  Sungchan Park  ;  Sun Ouck Kim  ;  Dong Soo Ryu  ;  Minki Baek  ;  Sang Don Lee  ;  Jung Won Lee  ;  Young Jae Im  ;  Sang Won Han  ;  Jae Min Chung  ;  Min Hyun Cho  ;  Tae Sun Ha  ;  Won Yeol Cho  ;  Hong Jin Suh  ;  The Korean Children's Continence and Enuresis Society 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.29(11) : 1550-1554, 2014 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2014
MeSH
Child ; Child, Preschool ; Cholinergic Antagonists/adverse effects ; Cholinergic Antagonists/therapeutic use* ; Constipation/etiology ; Dizziness/etiology ; Female ; Humans ; Male ; Retrospective Studies ; Treatment Outcome ; Urinary Bladder, Overactive/drug therapy*
Keywords
Anticholinergics ; Efficacy ; Overactive Urinary Bladder ; Tolerability ; Urinary Incontinence
Abstract
We investigated the efficacy and tolerability of various anticholinergics in Korean children with non-neurogenic overactive bladder (OAB). A total of 326 children (males:females= 157:169) aged under 18 yr (mean age 7.3±2.6 yr) who were diagnosed with OAB from 2008 to 2011 were retrospectively reviewed. The mean duration of OAB symptoms before anticholinergic treatment was 16.9±19.0 months. The mean duration of medication was 5.6±7.3 months. Urgency urinary incontinence episodes per week decreased from 1.9±3.1 to 0.4±1.5 times (P<0.001). The median voiding frequency during daytime was decreased from 9.2±5.4 to 6.3±4.2 times (P<0.001). According to 3-day voiding diaries, the maximum and average bladder capacity were increased from 145.5±66.9 to 196.8±80.3 mL and from 80.8±39.6 to 121.8±56.5 mL, respectively (P<0.001). On uroflowmetry, maximum flow rate was increased from 17.6±8.4 to 20.5±8.2 mL/sec (P<0.001). Adverse effects were reported in 14 (4.3%) children and six children (1.8%) discontinued medication due to adverse effects. Our results indicate that anticholinergics are effective to improve OAB symptoms and tolerability was acceptable without severe complications in children.
Files in This Item:
T201404582.pdf Download
DOI
10.3346/jkms.2014.29.11.1550
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Im, Young Jae(임영재)
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138437
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