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Scattered psammomatous calcifications around papillary thyroid carcinoma

Authors
 Yong Sang Lee  ;  Soon Won Hong  ;  Hang Seok Chang  ;  Cheong Soo Park 
Citation
 WORLD JOURNAL OF SURGERY, Vol.38(7) : 1738-1742, 2014 
Journal Title
 WORLD JOURNAL OF SURGERY 
ISSN
 0364-2313 
Issue Date
2014
MeSH
Adult ; Calcinosis/pathology* ; Calcinosis/surgery ; Carcinoma/pathology* ; Carcinoma/surgery ; Carcinoma, Papillary ; Female ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Prognosis ; Retrospective Studies ; Thyroid Neoplasms/pathology* ; Thyroid Neoplasms/surgery ; Thyroidectomy
Keywords
Thyroid Cancer ; Papillary Thyroid Carcinoma ; Central Lymph Node Metastasis ; Lymphocytic Thyroiditis ; Neck Node Metastasis
Abstract
BACKGROUND: Although psammomatous calcification is a characteristic pathologic feature of papillary thyroid carcinoma (PTC), the clinical meaning of histologically determined scattered psammomatous calcifications around PTC is unknown. OBJECTIVE: The aim of this study was to evaluate the clinical significance of scattered psammomatous calcifications around PTC. MATERIALS AND METHODS: Between January 2009 and July 2009, a total of 546 patients who underwent total thyroidectomy for PTC were enrolled. They were classified into two groups: patients with scattered psammomatous calcifications and patients without psammomatous calcifications. The clinical findings, preoperative diagnostic findings, and histopathologic features were compared between the two groups. RESULTS: Scattered psammomatous calcifications around PTC were found in 209 patients (38 %), and mostly in younger patients (p = 0.007), those with infiltrative tumor margin (p = 0.022), those with capsule invasion (p = 0.013), and those with lymph node metastasis (p < 0.001). No statistical significance was found in gender, tumor size, multiplicity, and coexisting lymphocytic thyroiditis. CONCLUSIONS: Although further studies with large-scale, long-term follow-up will be necessary to validate the relationship between scattered psammomatous calcifications and prognosis, scattered psammomatous calcification around PTC may have correlations with the aggressiveness of the PTC.
Full Text
http://link.springer.com/article/10.1007/s00268-014-2460-z
DOI
10.1007/s00268-014-2460-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Cheong Soo(박정수)
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138339
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