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Reciprocal interaction between carcinoma-associated fibroblasts and squamous carcinoma cells through interleukin-1α induces cancer progression.

Authors
 Jung Yoon Bae  ;  Eun Kyoung Kim  ;  Dong Hyun Yang  ;  Xianglan Zhang  ;  Young Jin Park  ;  Doo Young Lee  ;  Chung Min Che  ;  Jin Kim 
Citation
 Neoplasia, Vol.16(11) : 928-938, 2014 
Journal Title
 Neoplasia 
ISSN
 1522-8002 
Issue Date
2014
Abstract
Crosstalk between cancer cells and carcinoma-associated fibroblasts (CAFs) has earned recognition as an interaction that plays a pivotal role in carcinogenesis. Thus, we attempted to clarify whether increase in the level of CAFs promotes cancer progression by proportionally enhancing the interaction between cancer cells and CAFs. We first analyzed clinical correlation between the levels of fibroblasts and cancer progression and found that the level of CAFs made a noticeable difference on the prognosis of patients with oral squamous cell carcinoma (OSCC). In vivo animal study also demonstrated that tumor volume depended on the dose of CAFs that was co-injected with OSCC cells. The same tendency was observed in an in vitro study. We also found that interleukin-1α (IL-1α) secreted from OSCC cells had dual effects on CAFs: IL-1α not only promoted the proliferation of CAFs but also upregulated the secretion of cytokines in CAFs such as CCL7, CXCL1, and IL-8. The induction activity of cytokine secretion by IL-1α surpassed that of proliferation in OSCC cells. In summary, we unraveled an important interactive mechanism of carcinogenesis: IL-1α released from carcinoma stimulates the proliferation of CAFs and the simultaneous increase in cytokine secretion from CAFs promotes cancer progression in human OSCC. On the basis of these findings, we propose that the level of CAFs is eligible for being selected as a prognostic factor that will be useful in routine diagnosis. We also propose that blockage of reciprocal interaction between cancer cells and CAFs will provide an insight for developing novel chemotherapeutic strategy.
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DOI
10.1016/j.neo.2014.09.003
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
Yonsei Authors
김은경(Kim, Eun Kyoung)
김진(Kim, Jin)
박영진(Park, Young Jin)
배정윤(Bae, Jung Yoon) ORCID logo https://orcid.org/0000-0001-8342-6987
이두영(Lee, Doo Young)
장향란(Zhang, Xiang Lan)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138287
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