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Prevalence of congenital heart defects associated with Down syndrome in Korea.

Authors
 Min A Kim  ;  You Sun Lee  ;  Nan Hee Yee  ;  Jeong Soo Choi  ;  Jung Yun Choi  ;  Kyung Seo 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.29(11) : 1544-1549, 2014 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2014
MeSH
Adult ; Asian Continental Ancestry Group ; Birth Weight ; Chromosome Aberrations ; Databases, Factual ; Down Syndrome/complications* ; Ductus Arteriosus, Patent/epidemiology ; Female ; Gestational Age ; Heart Defects, Congenital/epidemiology* ; Heart Defects, Congenital/etiology ; Heart Septal Defects/epidemiology ; Heart Septal Defects, Atrial/epidemiology ; Heart Septal Defects, Ventricular/epidemiology ; Humans ; Male ; Prevalence ; Republic of Korea/epidemiology
Keywords
Down Syndrome ; Heart Defects, Congenital ; Prevalence, Korea
Abstract
Congenital heart defect (CHD) is common in infants with Down syndrome (DS), which is the principle cause of mortality. However, there is no data available for the frequency and types of CHD in infants with DS in Korea. We investigated the frequency of CHD in infants with DS in Korea. After the survey on birth defects was conducted throughout the country, the prevalence of CHD in DS in 2005-2006 was calculated. This study was conducted based on the medical insurance claims database of the National Health Insurance Corporation. The number of total births in Korea was 888,263 in 2005-2006; of them, 25,975 cases of birth defects were identified. The prevalence of DS was 4.4 per 10,000 total births, accounting for 1.5% of all birth defects. Of the 394 infants with DS, 224 (56.9%) had a CHD. Atrial septal defect was the most common defect accounting for 30.5% of DS followed by ventricular septal defect (19.3%), patent duct arteriosus (17.5%), and atrioventricular septal defect (9.4%). Our study will be helpful to demonstrate the current status of DS and to identify the distribution of CHD in infants with DS in Korea.
Files in This Item:
T201404217.pdf Download
DOI
10.3346/jkms.2014.29.11.1544
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min A(김민아)
Seo, Kyung(서경)
Lee, You Sun(이유선)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138273
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