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LDL Cholesterol Affects Clinical Outcomes in Incident Hemodialysis Patients During the Early Stages of Dialysis

Authors
 Kim C.H.  ;  Kim S.J.  ;  Lee M.J.  ;  Kwon Y.E.  ;  Kim Y.L.  ;  Park K.S.  ;  Ryu H.J.  ;  Oh H.J.  ;  Han S.H.  ;  Yoo T.-H.  ;  Kim Y.-L.  ;  Kim Y.S.  ;  Yang C.W.  ;  Kim N.-H.  ;  Kang S.-W.  ;  Park J.T. 
Citation
 BLOOD PURIFICATION, Vol.38(2) : 131-139, 2014 
Journal Title
 BLOOD PURIFICATION 
ISSN
 0253-5068 
Issue Date
2014
MeSH
Adult ; Aged ; Cardiovascular Diseases/blood* ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood* ; Female ; Humans ; Kidney Failure, Chronic/blood* ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Renal Dialysis* ; Risk Factors ; Survival Analysis ; Time Factors ; Treatment Outcome
Keywords
Clinical outcome ; End-stage renal disease ; Hemodialysis ; Low-density lipoprotein cholesterol
Abstract
BACKGROUND/AIMS: Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis. METHODS: A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables. RESULTS: Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP. CONCLUSION: Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.
Full Text
http://www.karger.com/Article/FullText/367803
DOI
10.1159/000367803
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kwon, Young Eun(권영은)
Kim, Seung Jun(김승준)
Kim, Yung Ly(김영리)
Kim, Chan Ho(김찬호)
Ryu, Han Jak(류한작)
Park, Kyoung Sook(박경숙)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Oh, Hyung Jung(오형중)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Mi Jung(이미정)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138251
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