LDL Cholesterol Affects Clinical Outcomes in Incident Hemodialysis Patients During the Early Stages of Dialysis

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Authors: Kim C.H. ; Kim S.J. ; Lee M.J. ; Kwon Y.E. ; Kim Y.L. ; Park K.S. ; Ryu H.J. ; Oh H.J. ; Han S.H. ; Yoo T.-H. ; Kim Y.-L. ; Kim Y.S. ; Yang C.W. ; Kim N.-H. ; Kang S.-W. ; Park J.T.

MeSH: Adult ; Aged ; Cardiovascular Diseases/blood* ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood* ; Female ; Humans ; Kidney Failure, Chronic/blood* ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Renal Dialysis* ; Risk Factors ; Survival Analysis ; Time Factors ; Treatment Outcome

Keywords: Clinical outcome ; End-stage renal disease ; Hemodialysis ; Low-density lipoprotein cholesterol

Abstract: BACKGROUND/AIMS: Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis.

METHODS: A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables.

RESULTS: Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP.

CONCLUSION: Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

Yonsei Authors: Kang, Shin Wook(강신욱) https://orcid.org/0000-0002-5677-4756
Kwon, Young Eun(권영은)
Kim, Seung Jun(김승준)
Kim, Yung Ly(김영리)
Kim, Chan Ho(김찬호)
Ryu, Han Jak(류한작)
Park, Kyoung Sook(박경숙)
Park, Jung Tak(박정탁) https://orcid.org/0000-0002-2325-8982
Oh, Hyung Jung(오형중)
Yoo, Tae Hyun(유태현) https://orcid.org/0000-0002-9183-4507
Lee, Mi Jung(이미정)
Han, Seung Hyeok(한승혁) https://orcid.org/0000-0001-7923-5635

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