132 183

Cited 4 times in

Ethyl-3,4-dihydroxybenzoate with a dual function of induction of osteogenic differentiation and inhibition of osteoclast differentiation for bone tissue engineering.

DC FieldValueLanguage
dc.contributor.author구민아-
dc.contributor.author권병주-
dc.contributor.author박종철-
dc.contributor.author이미희-
dc.date.accessioned2015-12-28T10:53:34Z-
dc.date.available2015-12-28T10:53:34Z-
dc.date.issued2014-
dc.identifier.issn1937-3341-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138250-
dc.description.abstractThe current approach in biomaterial design of bone implants is to induce in situ regeneration of bone tissue, thus improving integration of the implants and reducing their failure. Therefore, ethyl-3,4-dihydroxybenzoate (EDHB), which stimulates differentiation of osteoblasts and the resultant bone formation, should be studied. In this study, the osteoinductive ability of EDHB in preosteoblasts and human mesenchymal stem cells was examined. EDHB for future use in bone tissue engineering was evaluated by examination of early markers of differentiation (such as alkaline phosphatase [ALP] activity and collagen type I expression) and late markers of osteoblast differentiation (bone nodule formation). As bone remodeling and implant osteointegration depend not only on osteoblast response but also on interaction of the biomaterial with bone-resorbing osteoclasts, differentiation of osteoclasts in response to the compounds was also observed. For in vivo study, alginate gel comprised of EDHB and cells was transplanted into the back subcutis of mice. Our results show that EDHB might have beneficial effects through regulation of both osteoblast and osteoclast differentiation. Therefore, we suggest that EDHB could be a strong candidate for dual regulation to increase osteoblast differentiation and decrease osteoclast differentiation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2975~2984-
dc.relation.isPartOfTISSUE ENGINEERING PART A-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESH3T3 Cells-
dc.subject.MESHAnimals-
dc.subject.MESHBone Development/drug effects-
dc.subject.MESHBone Development/physiology-
dc.subject.MESHCell Differentiation/drug effects-
dc.subject.MESHCell Differentiation/physiology-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHHydroxybenzoates/administration & dosage*-
dc.subject.MESHIntercellular Signaling Peptides and Proteins/administration & dosage-
dc.subject.MESHMice-
dc.subject.MESHOsteoblasts/cytology*-
dc.subject.MESHOsteoblasts/drug effects-
dc.subject.MESHOsteoblasts/physiology*-
dc.subject.MESHOsteoclasts/cytology*-
dc.subject.MESHOsteoclasts/drug effects-
dc.subject.MESHOsteoclasts/physiology*-
dc.subject.MESHOsteogenesis/drug effects-
dc.subject.MESHOsteogenesis/physiology*-
dc.subject.MESHTissue Engineering/methods*-
dc.titleEthyl-3,4-dihydroxybenzoate with a dual function of induction of osteogenic differentiation and inhibition of osteoclast differentiation for bone tissue engineering.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학)-
dc.contributor.googleauthorByeong Ju Kwon-
dc.contributor.googleauthorMi Hee Lee-
dc.contributor.googleauthorMin Ah Koo-
dc.contributor.googleauthorJae Jin Han-
dc.contributor.googleauthorJong Chul Park-
dc.identifier.doi10.1089/ten.TEA.2013.0567-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00190-
dc.contributor.localIdA00218-
dc.contributor.localIdA01662-
dc.contributor.localIdA02777-
dc.relation.journalcodeJ02735-
dc.identifier.eissn1937-335X-
dc.identifier.pmid24784993-
dc.contributor.alternativeNameKoo, Min Ah-
dc.contributor.alternativeNameKwon, Byeong Ju-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.alternativeNameLee, Mi Hee-
dc.contributor.affiliatedAuthorKoo, Min Ah-
dc.contributor.affiliatedAuthorKwon, Byeong Ju-
dc.contributor.affiliatedAuthorPark, Jong Chul-
dc.contributor.affiliatedAuthorLee, Mi Hee-
dc.citation.volume20-
dc.citation.number21~22-
dc.citation.startPage2975-
dc.citation.endPage2984-
dc.identifier.bibliographicCitationTISSUE ENGINEERING PART A, Vol.20(21~22) : 2975-2984, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.