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Multimodality treatment with radiotherapy for huge hepatocellular carcinoma.

Authors
 H J Han  ;  M S Kim  ;  J Cha  ;  J S Choi  ;  K H Han  ;  J Seong 
Citation
 Oncology, Vol.87(Suppl 1) : 82-89, 2014 
Journal Title
 Oncology 
ISSN
 0030-2414 
Issue Date
2014
MeSH
Adult ; Aged ; Biomarkers, Tumor/blood ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology* ; Carcinoma, Hepatocellular/radiotherapy ; Carcinoma, Hepatocellular/therapy* ; Dose Fractionation ; Female ; Hepatectomy ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/diagnosis ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology* ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/therapy* ; Male ; Medical Records ; Middle Aged ; Neoplasm Staging ; Prognosis ; Radiotherapy, Adjuvant* ; Retrospective Studies ; Risk Factors ; Treatment Failure ; Treatment Outcome ; alpha-Fetoproteins/metabolism
Keywords
Hepatocellular carcinoma ; Radiotherapy ; Multimodality treatment
Abstract
BACKGROUND: For huge hepatocellular carcinoma (HCC), therapeutic decisions have varied from local therapy to systemic therapy, with radiotherapy (RT) playing only a palliative role. In this study, we investigated whether multimodality treatment involving RT could be effective in huge HCC. RESULTS: This study was performed in 116 patients with HCC >10 cm. The number of patients in stage II, III and IV was 12, 54 and 50, respectively. RT was given as a combined modality in most patients. The median dose was 45 Gy, with 1.8 Gy per fraction. The median overall survival (OS) and progression-free survival (PFS) were 14.8 and 6.5 months, respectively. The median infield PFS was not reached. Infield failure, outfield intrahepatic and extrahepatic failure were observed in 8.6, 18.1, and 12.1% of patients, respectively. For OS and PFS, number of tumors, initial alpha-fetoprotein (AFP) level, treatment response, percent AFP decrement, and hepatic resection were significant prognostic factors. Tumor characteristics and treatment response were significantly different between long-term survivors and the other patients. CONCLUSION: Although huge HCC presents an aggressive clinical course, multimodality approaches involving RT can offer an opportunity for prolonged survival.
Full Text
http://www.karger.com/Article/FullText/368150
DOI
10.1159/000368150
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Sun(김미선)
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Cha, Ji Hye(차지혜)
Choi, Jin Sub(최진섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138233
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