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Correlation between coronary artery calcium score and aortic diameter in a high-risk population of elderly male hypertensive patients.

Authors
 In Jeong Cho  ;  Ran Heo  ;  Hyuk Jae Chang  ;  Sanghoon Shin  ;  Chi Young Shim  ;  Geu Ru Hong  ;  James K. Min  ;  Namsik Chung 
Citation
 CORONARY ARTERY DISEASE, Vol.25(8) : 698-704, 2014 
Journal Title
 CORONARY ARTERY DISEASE 
ISSN
 0954-6928 
Issue Date
2014
MeSH
Age Factors ; Aged ; Aorta, Abdominal*/diagnostic imaging ; Aorta, Thoracic/diagnostic imaging ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/epidemiology* ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/epidemiology* ; Aortography/methods ; Chi-Square Distribution ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology* ; Dilatation, Pathologic ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology* ; Linear Models ; Male ; Multivariate Analysis ; Predictive Value of Tests ; Prevalence ; Prospective Studies ; Republic of Korea/epidemiology ; Risk Assessment ; Risk Factors ; Sex Factors ; Smoking/adverse effects ; Smoking/mortality ; Tomography, X-Ray Computed ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/epidemiology*
Abstract
BACKGROUND: Studies on the relationship between coronary artery calcium and aortic diameter are scarce. The aim of the current study was to evaluate the correlation between coronary artery calcium score (CACS) and maximal thoracic and abdominal aortic diameters in a population of elderly (>65 years) male hypertensive patients at high risk for coronary artery disease. PATIENTS AND METHODS: From June 2012 to April 2013, we prospectively enrolled 393 male hypertensive patients older than 65 years of age who had no history of aortic aneurysm. Coronary artery calcium and maximal diameters of the ascending thoracic aorta (ATAmax), descending thoracic aorta (DTAmax), and abdominal aorta (AAmax) were measured using noncontrast computed tomography imaging. Aortic diameters are indexed to body surface area (BSA). Participants were divided into five groups according to CACS (0, 1-10, 10-100, 100-400, and >400). RESULTS: The mean ATAmax/BSA, DTAmax/BSA, and AAmax/BSA were 22.0±2.7, 16.3±1.9, and 13.0±2.9 mm, respectively. On multivariate analysis, ATAmax/BSA was associated independently with age, diabetes, and history of aortic valve replacement (all P<0.001). DTAmax/BSA was associated independently with age (P<0.001). However, there were no significant correlations between thoracic aorta diameter and CACS. In contrast, AAmax/BSA was associated independently with CACS as well as age and history of smoking (P=0.014, 0.003, and 0.019, respectively). Abdominal aortic aneurysm (>30 mm) was more prevalent in patients with a CACS of 400 or more compared with the others (14 vs. 3%, P<0.001). CONCLUSION: CACS was associated with increased abdominal aorta diameter, but not with thoracic aorta diameter. Therefore, screening for an abdominal aortic aneurysm is warranted in patients with a high risk of coronary artery disease and a high CACS. However, the necessity for thoracic aortic aneurysm screening is not clear in these patients.
Files in This Item:
T201404153.pdf Download
DOI
10.1097/MCA.0000000000000150
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sang Hoon(신상훈)
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Chung, Nam Sik(정남식)
Cho, In Jeong(조인정)
Heo, Ran(허란)
Hong, Geu Ru(홍그루) ORCID logo https://orcid.org/0000-0003-4981-3304
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138232
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