The effects of chitosan oligosaccharide supplementation on glucose control in subjects with pre-diabetes

Abstract

The effects of chitosan oligosaccharide supplementation on glucose control in subjects with pre-diabetesHee Jun KimDept. of Science for AgingThe Graduate SchoolYonsei UniversityWe aimed to evaluate the effect of chitosan oligosaccharide supplementation on glucose control in subjects with pre-diabetes. This study was a randomized, double-blind, placebo-controlled clinical trial. Subjects with pre-diabetes were randomly assigned to the chitosan oligosaccharide intervention group or the placebo group for 12-weeks. We assessed the serum levels of glucose, insulin, and C-peptide by 2-hour value in the 75g oral glucose tolerance test (OGTT), HbA1c, pro-inflammatory cytokines, and plasma adiponectin at baseline and after the 12 -week intervention. The treatment group showed a significant decrease in serum glucose level at 30 min (p=0.013) and at 60 min (p=0.028). The change of serum glucose level at 60 min was significant in the treatment group compared with the placebo group (p=0.030). Also, the plasma level of hemoglobin A1c (HbA1c) (p=0.023), the pro-inflammatory cytokines (IL-6 and TNF-) and the plasma adiponection were reduced in the chitosan oligosaccharide intervention group after the 12-week treatment. However, the placebo group did not show any significant changes in these biomarkers. In conclusion, the chitosan oligosaccharide supplementation may be effective for controlling serum glucose levels and postprandial glycemic responses in pre-diabetes.