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Human leukocyte antigen-G polymorphism and expression in breast cancer patients
DC Field | Value | Language |
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dc.contributor.author | 정세리 | - |
dc.date.accessioned | 2015-12-24T09:45:00Z | - |
dc.date.available | 2015-12-24T09:45:00Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/136474 | - |
dc.description | Dept. of Medicine/박사 | - |
dc.description.abstract | Human leukocyte antigen-G (HLA-G) is implicated in a tumor-driven immune escape mechanism in malignancies. The purpose of this study was to investigate the influence of HLA-G polymorphism and expression on breast cancer. Eighty patients with breast cancer and 80 healthy individuals were included in this study. HLA-G alleles were determined by direct DNA sequencing procedures from blood samples, and soluble HLA-G (sHLA-G) was detected by enzyme-linked immunosorbent assay (ELISA) from serum specimens. HLA-G expression in 73 breast cancer lesions was also analyzed by immunohistochemistry staining. The HLA-G 3'' untranslated region (UTR) 14 bp sequence insertion was analyzed and found to be associated with reduced risk of breast cancer susceptibility based on HLA-G expression in tissues (P=0.0407). Levels of sHLA-G were higher in the breast cancer group (median sHLA-G=117.2 U/mL) compared to the control group (median sHLA-G=10.1 U/mL, P<0.0001) and also presented a significant difference between the ductal carcinoma in situ and control (P<0.0001). The area under the receiver operating characteristic curve (AU-ROC) value of sHLA-G for distinguishing breast cancer from normal controls was 0.89. A similar AU-ROC value was observed for detecting metastasis from all other groups (0.89, P<0.0001), which was greater than that of the current tumor marker CA15-3 (0.54, P<0.0001). Thus, HLA-G polymorphism and expression may be involved in breast carcinogenesis and sHLA-G concentrations could be used as a diagnostic marker for detecting breast cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Human leukocyte antigen-G polymorphism and expression in breast cancer patients | - |
dc.title.alternative | 유방암 환자에서 사람백혈구항원-G의 다형성과 발현 | - |
dc.type | Thesis | - |
dc.identifier.url | https://ymlib.yonsei.ac.kr/catalog/search/book-detail/?cid=CAT000000195073 | - |
dc.contributor.alternativeName | Jeong, Se Ri | - |
dc.type.local | Dissertation | - |
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