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Coenzyme Q10 reduced blood glucose and intracellular inflammation in an animal model of type 2 diabetes mellitus

Other Titles
 당뇨병 동물모델에서 코엔자임 Q10의 혈중 공복혈당 개선 및 세포 내 염증지표 감소 효과 
Authors
 이용제 
Issue Date
2013
Description
Dept. of Medicine/박사
Abstract
Objectives: We examined the effects of coenzyme Q10 supplementation on metabolic parameters including fasting plasma glucose, insulin sensitivity, and intracellular inflammation in db/db mice, a diabetic animal model.Materials and Methods: Mice were divided into 3 groups: normal control mice with chow diet (n=6), db/db mice with high-fat diet (n=9), and db/db mice with high-fat diet and coenzyme Q10 administration (20 mg/kg/day) for 12 weeks (n=9). After 12 weeks, metabolic parameters including fasting blood glucose concentrations, hemoglobin A1C (HbA1c), insulin and lipid profiles were determined using high-performed liquid chromatography. The expression of mitochondrial biogenesis markers including PGC-1α and T-fam were measured in cardiac and skeletal muscle tissues. Similarly, inflammatory markers such as IL-6, COX-2, and CRP were measured in liver tissues.Results: After 12 weeks of treatment, the glucose index including fasting blood glucose levels, HbA1C, and homeostatic model assessment of insulin resistance (HOMA-IR) were significantly decreased in coenzyme Q10-treated db/db mice compared with untreated control db/db mice. Compared with normal controls, the expressions of proteins related to mitochondrial biogenesis such as PGC-1α and T-fam were higher in db/db control mice, whereas the expressions of these proteins were significantly decreased in db/db mice treated with coenzyme Q10. Coenzyme Q10 treated db/db mice exhibited a significant decrease in the mRNA expression of IL-6, COX-2, and CRP compared with normal control and db/db control mice. We calculated inflammatory scores by summing the mRNA levels of IL-6, COX-2, and CRP, and found that while scores were significantly increased in untreated db/db control mice, they tended to decrease in coenzyme Q10-treated db/db mice.Conclusion: We observed significant decreases in fasting blood glucose levels and insulin resistance associated with significant reductions in inflammatory markers in coenzyme Q10 treated db/db mice.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 3. Dissertation
Yonsei Authors
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/136343
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