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Mechanisms of fat distribution with aging : regulation by PPARγ action in a type 2 diabetic animal model

Other Titles
 제2형 당뇨병 동물 모델에서 노화와 관련된 지방 분포 변화의 기전 : PPARγ 효현제의 작용에 의한 조절 
Authors
 박세은 
Department
 Dept. of Internal Medicine (내과학교실) 
Issue Date
2013
Description
Dept. of Medicine/박사
Abstract
Visceral fat accretion is a hallmark of aging and is associated with aging-induced metabolic dysfunction. Many studies have reported that the peroxisome proliferator–activated receptor (PPARγ) agonist rosiglitazone improves insulin sensitivity by redistributing fat from visceral fat to subcutaneous fat. The purpose of this study was to investigate the underlying mechanisms by which aging affects adipose tissue remodeling in a type 2 diabetic animal model and through which PPARγ activation modulates aging-related fat tissue distribution. At the ages of 21, 31 and 43 weeks, male Otusuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes mellitus, were evaluated for aging-related effects on adipose tissue metabolism. Aging increased adipocyte cell size and the ratio of visceral fat weight to subcutaneous fat weight (V/S ratio). The serum levels of glucose, insulin and free fatty acid (FFA) were also increased. During aging, the mRNA expression of the genes involved in lipogenesis and fatty acid recycling were highly expressed in visceral fat as compared to subcutaneous fat. These changes were paralleled by immunohistochemical analyses. Aging increased mRNA expression related to lipolysis in both types of fat depots. The changes in the genes involved in lipid oxidation and energy expenditure, such as PDK2, mCPT1 and Acadl, varies during aging. After six weeks of rosiglitazone treatment in the OLETF rats, starting at 15 weeks of age, the PPARγ agonist resulted in fat redistribution with a decreasing V/S ratio and improved glucose intolerance. Compared with the untreated OLETF rats, the genes involved in lipogenesis and fatty acid cycling were decreased in visceral fat, whereas there were no significant changes of mRNA expression associated with lipid oxidation. Our data suggests that fat distribution was changed by stimulating the lipid uptake and esterification in the visceral fat as compared to the subcutaneous fat, thus altering the lipid oxidation during aging. Conversely, these changes might be modulated by PPAR γ action in a type 2 diabetic animal model.
Full Text
https://ymlib.yonsei.ac.kr/catalog/search/book-detail/?cid=CAT000000129874
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 3. Dissertation
Yonsei Authors
Park, Se Eun(박세은)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/136295
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