Expression of collagenases (MMP-1,8,13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients

Abstract

[한글]

[영문]Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play an important role in diverse physiologic and pathologic processes including embryonic development, tissue morphogenesis, wound repair, arthritis, and cancer. The structure of temporomandibular joint (TMJ) is one of the valuable parts of maintaining joint function, but when simple mechanical abrasion, injury, or metabolic reaction induce structural injury with the strong activity of matrix-degradation enzyme, those undetectable symptoms develop into more serious ones such as pain or limitation in mouth movement. In this study, the expression of collagenase-1, 2, 3 (MMP-1, 8, 13) and TIMP-1 in the retrodiscal tissue of TMJ disorder patients were examined in order to evaluate the relation of these enzymes and TMJ disorder by comparing magnetic resonance imaging, and operative findings. All the experimental cases showed MMP-1, 8, 13 and TIMP-1 expression but range or cell type of the expression was different. MMP-13 played a critical role in degrading of osteoarthritis as it was the predominant collagenase in collagen type II and it could also worsen internal derangement as breakdown enzyme of collagen of retrodiscal tissue in TMJ. MMP-1 was related to degeneration of osteoarthritis and MMP-8 was not specifically related to TMJ disorder. TIMP-1 seemed to show stronger role in internal derangement than osteoarthritis. This study could not explain the causal relation of imbalance between MMP and TIMP, but the activity of TIMP, which varied depending on levels of TMJ disorders, could be used as the criteria of prevention of progressive diseases as TIMP controls collagenases.