Effects of black soy peptide supplementation on glucose control in subjects with prediabetes and newly diagnosed type 2 diabetes mellitus

Abstract

[한글]

[영문]The present study aimed to determine the effect of black soy peptide supplementation on glucose control in subjects with prediabetes (impaired fasting glucose; IFG or impaired glucose tolerance; IGT) and newly diagnosed type 2 diabetes mellitus (DM). In this double-blind, placebo-controlled study, subjects with prediabetes and type 2 DM were randomly assigned to the placebo control group or the black soy peptide intervention group. We determined fasting serum concentrations of glucose, hemoglobin A1c (HbA1c), insulin, and free fatty acids (FFAs), performed a 2-h postload glucose test (2-h PG), and compared serum lipid profiles before and after the 12-week supplementation. Particularly, subjects with fasting glucose ≥ 110 mg/dL who consumed black soy peptides demonstrated a tendency to the decrease of fasting glucose levels (p=0.098 by two tail-test / p=0.049 by one tail-test) and had a significant reduction in 2-h PG level (p=0.012 by two tail-test / p=0.006 by one tail-test), compared with baseline levels. The changes in 2-h PG levels were also statistically significant in the intervention group (-41.25 ± 13.67 mg/dL) compared with the placebo group (12.42 ± 9.80 mg/dL; p=0.015 by two tail-test / p=0.008 by one tail-test). In contrast, HbA1c levels were not significantly improved by the dietary intervention. In conclusion, black soy peptide supplementation may be beneficial to control fasting blood glucose levels and 2-h postload glucose levels, particularly in subjects with fasting glucose ≥ 110 mg/dL.