한국인 침윤성 자궁경부암 환자에 있어서의 HLA-DR항원 분포에 관한 연구

Abstract

[영문]

[한글]

조직검사상 침윤성 자궁경부암으로 진단된 한국인 환자 55예를 대상으로 하여 HLA-DR항

원 분포를 조사하여 200예의 정상대조군과 비교 분석한 결과 다음과 같은 결과를 얻었다.

1. 침윤성 자궁경부암 환자 53예중 가장 맑은 출현빈도를 보인 항원은 DR2 (18예) 이였

고, DR4 (16예), DRw6 (14예), DR7 (14예), DR5(8예), DR1(6예), DRw8(4예)의 순이었다.

DR3은 정상대조군에서 l5%의 출현빈도를 나타낸 반면 침윤성 자궁경부암 환자에서는 전혀

나타나지 않았다.

2. 침윤성 자궁경부암 환자에서 정상대조군에 비해 DRw6가 통계학적으로 의의있게 증가

되었으며, DR3, DRw8이 있게 감소되어 나타났다(P<0.05).

HLA-DR ANTIGEN FREQUENCY in KOREAN PATIENTS with INVASIVE CARCINOMA of the CERVIX

K. S. Hwang, M.D.

Department of Medical Science The Graduate School Yonsei University

(Directed by Professor Tchan Kyu Park. M.D. )

HLA-DR typing was performed on 53 Korean patients with biopsy proved invasive

carcinoma of the cervix.

The patients were compared to 200 healthy controls.

The results were as follows :

1. Of 53 patients with invasive carcinoma of the cervix, the frequency of

antigens in decreasing older of frequency were DR2(18 cases), DR4(16 cases), DRw6

and DR7(14 cases), OR5(8 cases), DR1(6 cases), and DRw8(4 cases).

Although the frequency of DR3 in the normal subjects was 15%, it was not detected

in the patients with invasive carcinoma of the cervix.

2. A significant increase in the frequency in DRw6, and a significant decrease in

the frequencies of DR3 and DRw8 were demonstrated among the patients compared with

those in healthy controls (p < 0.05).