Prostaglandin이 임신중절에 미치는 영향에 대한 문헌적 고찰

Abstract

[영문]

[한글]

LITERATURE REVIEW ON EFFECT OF PROSTAGRANDIN FOR SUSPENSION OF CONCEPTION

Young Hie Choi

Departments of Public Health, Graduate School, Yonsei University

The rapid increasing population growth is becoming as one of the urgent problems

in the world, especially in the developing countries. Solving this problem, several

contraceptive methods and suspension of conception have been adoped in many

countries. However, when some women had an unwanted pregnancy they would try to

have an induced abortion which accompanies many dangerous side-effects such as

perforation of uterus, hemorrhage, infection, and death etc.

The author reviewed through literatures for the studies on prostaglandin, that

appear to be one of safe methods for induced labor and conception control.

The prostagladin is a family of lipids originally was discovered over 40 years

ago in seminal plasma. The substance has a wide striking of biological action.

Prostaglandin has a chemical structure being 20-carbon fatty acid containing a

cyclopentane ring from the essential unsaturated fatty acid.

Prostaglandin is distributed in tissue and body fluid o of human and animals.

High concentration of prostaglandin is particularly presented in the seminal plasma

and tissue of female reproductive tract. This suggests that the prostaglandin is

intimatly associated with reproductive physiology.

The responses of prostaglandin to reproductive tract for non-pregnant human

uterus are studied. PGE compounds inhibit the contraction of non-pregnant uterus

and PGF compounds stimulate it.

However, the sensitivity of the myometrium to prostaglandin changes during the

menstrual cycle. Non-pregnant uterus is 3 to 5 times more sensitive to inhibition

by PGE compounds at mid-cycle near ovulation time this inhibition of prostaglandin

on non-pregnant uterus in ovulation time may facilitate sperm and ovum migration

and play role in promoting capacitation and fertilization.

Responses of prostaglandin on the pregnant human uterus are differ from the each

phase of pregnancy.

Namely, responses of uterus at the first and mid-pregnancy to prostaglandin are

the stimulation of the uterine contraction and then cause the intra-uterine fetal

death. The threshold dose of PGE^^2 for the uterine contraction is 5 ㎍/min. and

that of PCG^^2 varies from 100㎍/min. to 300 ㎍/min. In late pregnancy at near or

term, the responses of uterurs are characterized by increasing the frequency and

amplitude of contraction with PGF^^2α (0.025 ㎍/㎏/min.) and PGF^^2(0.5㎍/min). As

increasing of contraction, the labor is induced and parturition is promoted.

Though, it is not widely known and has not been developed for practing suspension

of conception. PGE^^2(5㎍/min.) or PGF^^2α(100-300 ㎍/min.) are developing under

clinical bases and they will be available in near future. As it was mentioned,

there have been few side effects and dangers in using them.

Therefore, it is recommendable as one of the most effective and safe methods for

a suspension of conception. consequently, it will greatly contribute to the

population control in the future.