신경아세포종 33예의 치료성적

Abstract

[영문]

[한글]

신경아세포종(神經芽細胞腫)은 소아에서 중추신경계의 종양 다음으로 흔한 악성종양이

며, 면역기전 및 자연퇴행 등의 특성을 보이고 있다. 저자는 1974년 9월부터 1980년 9월

까지 약 6년간 연세 암센터 및 연세의대부속 세브란스병원 소아과에서 진단 및 치료받은

33명의 신경아세포종 환아에 대하여 임상연구 및 생존율을 산정하였다.

남여의 비는 1.2:1로 남아에 약간 더 많았고, 2세미만이 33.3%였으며 평균연령은 4.1

± 3.5세였다.

진단당시 병기는 제Ⅳ기가 57.6%로 가장 많았으며, 일반적으로 연령이 많은 환자는 내

원 당시부터 전이가 있는 경향을 보였다.

원발부위는 복부가 17예 (51.5%) 로 가장 많았고, 전이는 골(骨)전이가 9예 (42.9%)로

가장 많았다.

7예는 현재 2년이상 추적 관찰되고 있으며, 이들은 완치된 것으로 사료된다.

현재 추적중인 11예는 거의가 외과적 절제나 방사선 치료를 받았다.

생명표 방식에 의거하여 산정한 전체 환아의 생존율은 6개월에 77%, 12개월에 63%, 18

개월 이후는 45%였다.

Results of Treatment in 33 Patients with Neuroblastoma

Hak Yong Kim

Department of Medical Science The Graduate School Yonsei University

(Directed by Professor Duk Jin Yun, M.D.)

Neuroblastoma is a malignant neoplasm which arises from primitive sympathetic

neuroblasts. It is the second most common solid tumor in young children exceeded in

incidence only by brain tumors. This tumor shows immunological features and

spontaneous regression. But in spite of recent advances in multimodality therapy,

survival rate has not been improved much.

Thirty-three patients with neuroblastoma were reviewed who had been diagnosed and

treated between 1974 and 1980, and survival rate was calculated by life table

method.

The results of this study may be summarized briefly as follows :

1. Of the 33 patients, 18 were male and 15 were female. Their age ranged from 25

days to 13(11/12) years(mean 4.1±3.5 years). About 33 per cent of them were below

2 years.

2. Stage at the time of diagnosis showed that the patient with stage Ⅳ were most

frequent(57.6%). Generally the older patients tended to have more frequent

metastasis than the younger ones at the time of their first visit.

3. Abdomen was the most frequent prima교 tumor site(17 of 33 patients, 51.5%),

and bone was the most frequent metastatic site(9 of 21 patients, 42.9%).

4. Seven cartes are new on the follow-up list more than 2 years and have been

considered cured.

5. Most of the 11 cases whose progress has been closely followed had received

surgical excision or radiotherapy.

6. Ganglioneuroblastoma was present in 2 cases, and they are alive now since the

time of diagnosis.

7. Survival rate of total 33 patients calculated by life table method was 77 per

cent at 6th month, 63 per cent at 12th month, and 45 per cent after 18th month.