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Cerebral microbleeds in patients with Parkinson's disease according to cognitive status

Other Titles
 파킨슨 병 환자에서 인지 기능에 대한 뇌 미세출혈의 영향 
Issue Date
Dept. of Medicine/석사
Cerebral microbleeds (CMBs) are known to be associated with cognitive impairments in the elderly and in patients with various diseases, however, the nature of this association has not yet been evaluated in Parkinson’s disease (PD). In the present study, we analyzed the incidence of CMBs in PD according to cognitive status, and the impact of CMBs on cognitive performance was also evaluated. The CMBs in PD with dementia (n=36), mild cognitive impairment (MCI, n=46), or cognitively normal (n=41) were analyzed using a conventional T2* weighted gradient recalled echo images. Additionally, the relationship between the presence of CMBs and cognitive performance on individual tests of cognitive subdomains was analyzed using a detailed neuropsychological test. CMBs occurred more frequently in PD patients with dementia (36.1 %) compared to those with MCI (15.2%), those who are cognitively normal (14.6%), and normal controls (12.2%, p=0.025). However, the significant association of CMBs with PD dementia disappeared after adjusting white matter hyperintensities (WMHs) as a covariate. The frequencies of deep, lobar, and infratentorial CMBs did not differ among the four groups. After adjusting for age, sex, years of education, and WMHs, PD patients with CMBs had poorer performance in attention domain compared with those without CMBs (34.9 vs 42.6, p=0.018). The present data demonstrate that even though CMBs was inseparably associated with the presence of WMHs, CMBs occur more commonly in PD patients with dementia than in those without dementia. Additionally, the burden of CMBs may contribute to further cognitive impairment in PD.
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1. College of Medicine (의과대학) > Others (기타) > 2. Thesis
Yonsei Authors
Ham, Jee Hyun(함지현)
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