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Bone response to three different dental implant surfaces with Escherichia coli-derived recombinant human bone morphogenetic protein-2 in a rabbit model
DC Field | Value | Language |
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dc.contributor.author | 이재관 | - |
dc.date.accessioned | 2015-12-24T08:49:54Z | - |
dc.date.available | 2015-12-24T08:49:54Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/134323 | - |
dc.description | Dept. of Dental Science/박사 | - |
dc.description.abstract | Purpose: The objective of this study was to analyze orthotropic bone formation/remodeling of three different dental implant surfaces with/without recombinant human bone morphogenetic protein-2 derived from Escherichia coli (ErhBMP-2) in a rabbit model. Materials and Methods: Resorbable blasting media (RBM), sandblasted large grit and acid-etched (SLA), and Mg-incorporated oxidized (MgO) surfaces were coated with ErhBMP-2 (1.5 mg/mL). The implants were placed into the proximal tibia in six New Zealand White rabbits. Each rabbit received six different implants (three coated with ErhBMP-2 in one tibia and three uncoated implants in the other tibia) and the sites were closed submerging the implants. The animals received alizarin (2-week), calcein (4-week), and tetracycline (6-week) fluorescent bone markers; they were euthanized at 8-week for histomorphometric analysis.Results: Amount of coated ErhBMP-2 was 9.6±0.4 μg/MgO, 14.5±0.6 μg/RBM, and 29.9±3.8 μg/SLA per implant. Clinical healing was uneventful. Considering the entire implant, mean bone-implant contact (±SD) for the ErhBMP-2/RBM (35.4±5.1%) and ErhBMP-2/MgO (33.4±13.2%) implants was significantly greater compared with RBM (23.6±6.2%) and MgO (24.9±2.7%) implants (p<0.05). However, ErhBMP-2/SLA implants (19.1±7.2%) showed slightly lower bone-implant contact compared with SLA implants (23.4±3.8%; p > .05). Considering mean bone-implant contact in cortical bone and bone area within the threads, there were no significant differences between ErhBMP-2 coated and uncoated RBM and MgO implants. ErhBMP-2/SLA implants (32.9±7.8%) showed lower bone-implant contact than all other implant variations (range 39.9±18.1% - 51.3±9.2%; p < .05). Similarly there were no remarkable differences in new bone area with minor differences between implants. Conclusions: Within the limits of this study, absorbed ErhBMP-2 dose varies with implant surface characteristics in turn influencing local bone formation/remodeling. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Bone response to three different dental implant surfaces with Escherichia coli-derived recombinant human bone morphogenetic protein-2 in a rabbit model | - |
dc.title.alternative | 다양한 표면의 치과용 임플란트에서 ErhBMP-2 코팅에 따른 골 반응 변화 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Lee, Jae Kwan | - |
dc.type.local | Dissertation | - |
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