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Regulation of inflammatory signaling by TBL1/TBLR1
DC Field | Value | Language |
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dc.contributor.author | 이미희 | - |
dc.date.accessioned | 2015-12-24T08:49:31Z | - |
dc.date.available | 2015-12-24T08:49:31Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/134308 | - |
dc.description | Dept. of Medical Science/석사 | - |
dc.description.abstract | Dysregulation of inflammatory signaling has been implicated in the development of human diseases. Nuclear factor κB (NF-κB) plays a key role in regulating inflammatory signaling through controlling the NF-κB target genes. Recently, the formation of NF-κB and transducin β-like protein (TBL1) complex upon tumor necrosis factor-alpha (TNF-α) has been reported; however, little is known about how the corepressor TBL1 activates NF-κB function. Here, we show that both TBL1 and its related protein (TBLR1) are SUMOylated in a NF-κB mediated inflammatory signaling-dependent manner, and this modification is selectively reversed by SUMO-specific protease I (SENP1). SUMOylation of TBL1-TBLR1 increased the expression of NF-κB target genes by interacting with NF-κB and consequently led to activation of NF-κB-mediated inflammation. Conversely, SENP1 inhibited SUMOylation of TBL1-TBLR1, leading to reduction of NF-κB-mediated transcription. Finally, knockdown of TBL1 greatly impaired the production of interleukin (IL)-1beta, IL-6, and IL-8 in androgen-independent prostate cancer, PC-3 cells. Thus, our data reveal a mechanism for regulation of NF-κB mediated inflammation signal via the reversible SUMOylation of TBL1 and TBLR1. | - |
dc.description.statementOfResponsibility | prohibition | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Regulation of inflammatory signaling by TBL1/TBLR1 | - |
dc.title.alternative | TBL1/TBLR1에 의한 염증 신호 체계 조절 규명 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Lee, Mee Hee | - |
dc.type.local | Thesis | - |
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