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Feasibility of allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning with fludarabine and melphalan in patients relapsed after autologous hematopoietic stem cell transplantation
DC Field | Value | Language |
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dc.contributor.author | 홍정용 | - |
dc.date.accessioned | 2015-12-24T08:45:09Z | - |
dc.date.available | 2015-12-24T08:45:09Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/134142 | - |
dc.description | Dept. of Medicine/석사 | - |
dc.description.abstract | The current study was performed to determine the feasibility of allogeneic hematopoietic stem cell transplantation (HSCT) using reduced-intensity conditioning (RIC) with fludarabine and melphalan in patients relapsed after autologous HSCT. Twelve patients (multiple myeloma n=7, non-Hodgkin’s lymphoma n=3, acute myeloid leukemia n=2) received allogeneic HSCT using the RIC with fludarabine (25mg/m2 for 5days) and melphalan (140mg/m2 for 1day) for relapsed disease after a prior autologous HSCT. The graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine plus a mini-dose of methotrexate. All patients achieved a neutrophil or platelet engraftment in a median of 13.5 days and 17.5 days, respectively. The transplant-related mortality was 2 patients (16.7%). Grade II~IV acute GVHD and chronic extensive GVHD was noted in 4 (33.3%) and 1 patient (11.1%), respectively. Over a median follow-up duration of 12.5 months, 5 patients are currently alive without evidence of disease. The estimated non-relapse mortality (NRM) at 1 year was 28.4%. The estimated overall survival (OS) rate at 1 year 2was 58.3% and the estimated event-free survival (EFS) rate at 1 year was 41.7%. Allogeneic HSCT using RIC with fludarabine and melphalan appears to be feasible for a second HSCT in patients relapsed after autologous HSCT. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Feasibility of allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning with fludarabine and melphalan in patients relapsed after autologous hematopoietic stem cell transplantation | - |
dc.title.alternative | 자가 조혈모세포이식 이후 재발한 환자에서의 fludarabine과 melphan을 사용한 저강도 전처치 동종 조혈모세포이식 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Hong, Jung Yong | - |
dc.type.local | Thesis | - |
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