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Clinical outcomes and prognostic factors for surgically resected second primary lung cancer

Other Titles
 이차성 원발성 폐암의 수술 후 임상적 결과 및 예후인자 
Authors
 배미경 
Issue Date
2011
Description
Dept. of Medicine/석사
Abstract
This study was designed to analyze the predictive factors for survival in second primary lung cancer patients following operation. A total of 1,852 patients who underwent resection for primary lung cancer between January 1990 and December 2008 were reviewed, retrospectively. Of those patients, the 42 who underwent operation for second primary lung cancer were analyzed in this report. Nineteen patients were treated for synchronous second primary lung cancer and 23 patients were treated for metachronous second primary lung cancer. The overall five year survival rate for patients with synchronous second primary lung cancer was comparable to that of patients with single lung cancer (51.4% versus 48.7%, p= 0.755). The overall five year survival rate after the first tumor resection in patients with metachronous second primary lung cancer was significantly better than that of patients with single lung cancer (85.4% versus 48.7%, p= 0.003), but was not significantly different after the second tumor resection (77.0% versus 48.7%, p= 0.057). According to the univariate analysis, histologic concordance and the stage of both the first and second tumors were significant predictors of survival rate of synchronous tumor patients, while histologic concordance and second tumor stage were important for metachronous tumor survival rates. Surgically resected second primary lung cancer had a survival rate comparable with single lung cancer. Histologic concordance between the first and second tumors, and the pathological stage of the second tumor were important prognostic factors both in synchronous second primary lung cancer and metachronous second primary lung cancer. In addition, the pathological stage of the first tumor had a significant influence on the prognosis for synchronous second primary lung cancer.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/133996
Appears in Collections:
2. Thesis / Dissertation (학위논문) > 1. College of Medicine (의과대학) > Master's Degree (석사)
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