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Gamma oscillatory activity in relations to memory impairment

Other Titles
 기억력 저하에 관련된 감마 진동의 활성 
Issue Date
Dept. of Medicine/박사
Human gamma-band activity over 30Hz is thought to reflect attention, memory and higher cognitive processes. It has been widely reported that the gamma band shows increased activation during tasks involving memory, but it is not clear whether gamma oscillations truly reflect memory ability. We investigated the gamma oscillation changes during the maintenance phase in memory tasks and analyzed the differences between amnestic and multiple domain mild cognitive impairment (MCI, n=16) subjects and controls (CTR, n=19). Verbal and spatial delayed match to sample tasks were performed with simultaneous EEG recording and we specifically looked for gamma event-related desynchronization (ERD) during maintenance phase. There were no significant differences between the two groups in verbal delayed match to sample task. In spatial delayed match to sample task, gamma-ERD was stronger in controls than MCIs, and it was significantly correlated with memory ability scores and behavioral performance. We then investigated the gamma oscillation during memory tasks and its correlation with clinical measures of memory. Our result suggested that gamma oscillations reflect not only brain activity related to memory processes, but also the memory ability of subjects, with lower gamma oscillation activity reflecting greater efficiency of information processing. Gamma band activity may be a potential bio-physiological marker of memory function.
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2. Thesis / Dissertation (학위논문) > 1. College of Medicine (의과대학) > Ph.D. (박사)
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