Efficacy of in vitro adenosine triphosphate based chemotherapy response assay in gastric cancer

Abstract

Purpose: This study was done to investigate the clinical application efficacy of in vitro adenosine triphosphate based chemotherapy response assay(ATP-CRA) for decision making the adjuvant chemotherapy regimen of advanced gastric cancer patients.Method: ATP-CRA test was performed in advanced gastric cancer patients between June 2006 and October 2010. Data from 116 patients who underwent curative radical gastrectomy with postoperative adjuvant 5-fluorouracil(5-FU), its prodrugs and Cisplatin based chemotherapy were retrospectively reviewed. We analyzed disease free survival rate and overall survival rate along ATP-CRA results, TNM stages, chemotherapy regimens. ATP-CRA results was divided to cell death rate 50% or more as sensitive group, less than 50% as resistant group.Results: The clinicopathologic characteristics between stage II and III, chemotherapy regimen subgroups, ATP-CRA regimen specific sensitive and resistant groups were not statistical different. The three adjuvant chemotherapy regimen subgroups did not showed significant difference in disease free survival rate and overall survival rate. In ATP-CRA results, there were not statistically meaningful difference in disease free survival rate and overall survival rate between sensitive and resistant to 5-FU, Cisplatin, 5-FU or Cisplatin, 5-FU and Cisplatin, too.Conclusion: To decide adjuvant chemotherapy regimen along the ATP-CRA in gastric cancer patients did not provide help to increase disease free survival rate and overall survival rate.