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Preemptive analgesic effect of topical NSAIDs in postoperative pain relief after LASEK

Other Titles
 라섹 수술 후 통증에 대한 비스테로이드성 항염증 점안액의 선행 진통 효과 
Authors
 김세경 
Department
 Dept. of Ophthalmology (안과학교실) 
Issue Date
2012
Description
Dept. of Medicine/석사
Abstract
The aim of the study was to assess preemptive analgesic effect of topical NSAIDs (0.5% ketorolac tromethamine) on postoperative pain relief in patients undergoing LASEK and to examine the effect of topical NSAIDs on normal corneal sensation using corneal sensitivity test. In part 1, patients undergoing LASEK were randomized to receive 0.5% ketorolac in one eye and 0.3% ofloxacin (placebo) in the contralateral eye at 30, 20 and 10 minutes prior to LASEK. Postoperative pain and the levels of glare, tearing and irritation were assessed using a visual analog scale. A total of 62 eyes from 31 patients were enrolled. The mean postoperative pain score in the NSAID-pretreated eye was significantly lower than that in the placebo-received eye at postoperative hours 6, 12 and 24 (p<0.05). In part 2, ten subjects (Group 1) were randomized to instill 0.5% ketorolac in one eye and 0.3% ofloxacin (placebo) in the contralateral eye at every 10 minutes for 3 times. Another ten subjects (Group 2) were randomized to instill 0.5% ketorolac in one eye and 0.3% ofloxacin (placebo) in the contralateral eye at every 10 minutes for 3 times. After 10 minutes, 0.5% proparacaine was applied to both eyes. After 1, 2, and 6 hours, corneal sensitivity was measured. The mean corneal sensitivity was significantly lower in topical ketorolac-instilled eye than that of placebo-instilled eye for 2 hours after administration in both groups (p<0.05). Preemptive administration of topical NSAIDs before LASEK was effective in reducing acute postoperative pain.
Full Text
https://ymlib.yonsei.ac.kr/catalog/search/book-detail/?cid=CAT000000118738
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 2. Thesis
Yonsei Authors
Kim, Se Kyung(김세경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/133705
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