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신생아 각 장기 및 태반의 중금속 함유량에 관한 조사 연구

Other Titles
 (A) study of concentrations of heavy metals in the organs of the newborn and in the placentae. 
Authors
 이우길 
Issue Date
1979
Description
의학과/박사
Abstract
[한글] 2차대전 이후 급격한 산업의 발달과 인구의 증가는 대량 생산과 소비를 촉진하여 그 과정에서 방출된 각종 중금속이 함유된 화학물질이 환경을 오염시켜 사람에게 여러가지 피해를 주고 있어 외국에서는 이미 인체의 중금속 함유량과 생체에 미치는 영향에 관해서 많은 연구가 있지만 우리나라에서는 아직 인체의 중금속 함유량에 대한 조사가 안 되어 있다. 이에 저자는 1776년 5월부터 1978년 2월까지 연세대학교 의과대학 부속 세브란스병원 초생아실에서 사망한 신생아 32예 (남아 19예, 여아 13예)의 심장, 신장,간장 및 비장과 동 병원에서 분만한 태반 26예에서 AOAC방법(Horwitz 1975)에 의해서 비소, 카드뮴, 크롬 , 동, 철, 수은, 망간, 니켈, 납 및 아연의 함유량을 측정하고 다음과 같은 결과를 얻었다. 1. 심장의 각 중금속 평균 함유량은 비소 0.06, 카드뮴 1.42, 크롬 0.10, 동 4.32, 철 41.15, 수은 1.77, 망간 7.67, 니켈 0.08, 납 0.18, 아연 28.07㎍/gm이었다. 신장의 평균 함유량은 비소 0.11, 카드뮴 8.22, 크롬 0.05, 동 3.11, 철 42.25, 수은 1.85, 망간 0.15, 니켈 0.10, 납 0.40, 아연 15.22㎍/gm이었다. 간장의 평균 한유량은 비소 0.12, 카드뮴 3.78, 크롬 0.08, 동 10.46, 철 68.67, 수은 7.81,망간 0.43, 니켈 0.15, 납 0.64, 아연 25.36㎍/gm이었다. 비장의 평균 함유량은 비소 0.12, 카드뮴 6.41, 크롬 0.12, 동 4.49, 철 56.29, 수은 1.29, 망간 0.30, 니켈 0.25, 납 0.57, 아연 21.86㎍/gm이었다. 태반의 각 중금속의 평균 함유량은 비소 0.30, 카드뮴 5.04, 크롬 0.12, 동 0.92, 철 33.13, 수은 0.43, 망간 0.73, 니켈 0.21, 납 1.07, 아연 12.15㎍/gm이었다. 2. 장기중 남녀별 중금속 함유량에는 차이가 없었다. 3. 중금속별 주로 축적이 되는 장기는 비소와 카드뮴은 신장 및 비장, 크롬은 심장 및 비장, 동과 철은 간장, 수은은 심장 및 신장, 망간은 심장, 니켈은 비장, 납은 간장 및 비장,아연은 심장, 간장 및 비장이었다. 4. 장기별 각 중금속간에 상관성이 높은 경우는 심장에서 철:수은, 철:니켈, 니켈:아연 사이였고, 신장에서는 카드뮴:동, 카드뮴:수은, 동:철, 동:수은 사이였으며, 간장에서 비소:아연, 카드뮴:니켈, 크롬:망간, 크롬:니켈, 크롬:납, 동:철, 동:니켈, 철:니켈, 철:납, 망간:니켈 사이였고, 비장에서 비소:수은, 카드뮴:수은, 망간:아연 사이였다. 5. 태반중 비소, 카드뮴, 망간, 니켈 및 납의 함유량은 신생아의 장기보다 높았으나, 동 및 철의 함유량은 신생아 장기가 태반보다 높았다. 수은 및 아연의 함유량은 신생아 장기가 태반보다 높았으나 통계적인 차이는 없었으며 크롬의 함유량은 태반과 신생아 장기에서 비숫하였다.
[영문] Since World War II, rapid industrial development and population growth have expedited mass production and mass consumption. Chemical pollutants containing various hinds of heavy metals, which were transpired through that process, contaminated our environment and caused damage to mankind in many whys. So there already have been many studies of the concentrations of heavy metals in the human body and of their influence upon living organism in other countries. However, there has net yet hem any research on the concentrations of heavy metals in the human body in Korea. The purposes of this study are to examine and analytic the concentrations of various kinds of heavy metals in the organs of the newborn and the placenta of the mother, to compare the concentration of heavy metals by sex, and to observe and compare the correlations among organs, among heavy metals and between the organs of the newborn and the placenta. The studs measured by the AOAC method(Horwitz 1975) the concentrations of arsenic(As), cadmium(Cd), chromium(Cr), copper(Cu), iron(Fe), mercury(Hg), manganese(Mn), nickel(Ni), lead(Pb), and zinc(Zn) in the heart, kidney, liver, and spleen of 32 newborn(19 males and 13 females) died in the nursery of Severance Hospital, Yonsei University College of Medicine from May, 1976 to Feb., 1978 and in 26 placentae delivered at the same hopital. The study obtained the following results. 1. The average concentration of each heavy metal in the heart were: arsenic 0.06, cadmium 1.42, chromium 0.10, copper4.32, iron 41.15, mercury 1.77, manganese 0.67, nickel 0.08, lead 0.18, and zinc 28.07 ug/gm. The average concentrations in the kidney were: arsenic 0.11, cadmium 8.22, chromium 0.05, copper 3.11, iron 42.25, mercury 1.85, manganese 0.15, nickel 0.10, lead 0.40, and zinc 15.22 ug/gm. The average concentrations in the liver were: arsenic 0.02, cadmium 3.78, chromium 0.08, copper 10.46, iron 68.67, mercury 0.81, manganese 0.43, nickel 0.15, lead 0.64, and zinc 25.36 ug/gm. The average concentrations in the spleen were: arsenic 0.12, cadmium 6.41, chromium 0.12, copper 4.49, iron 56.29, mercury 1.29, manganese 0.30, nickel 0.25, lead 0.57, and zinc 21.86 ug/gm. In comparison the average concentration of each heavy metal in the placenta were: arsenic 0.30, cadmium 5.04, chromium 0.12, copper 0.92, iron 33.13, mercury 0.43, manganese 0.73, nickel 0.21, lead 1.07, and zinc 12.15 ug/gm. 2. There was no significant difference between the sexes in the concentrations of each heavy metal in each organ. 3. The organs in which earth heavy metal is chiefly concentrated were examined: arsenic is concentrated chiefly in the kidney and spleen; cadmium in the kidney and spleen: chromium in the heart and spleen: copper in the liver: iron in the liver; mercury in the heart and kidney: manganese in the heart: nickel in the spleen; lead in the liver and spleen; zinc in the heart, liver, and spleen. 4. High correlations among heavy metals concentrated in each organ were found in the case of the heart between iron and mercury, between iron and nickel, and between nickel and zinc; in the cast of the kidney between, cadmium and copper, between cadmium and mercury, between copper and iron, and between copper and mercury: in the case of the liver between arsenic and zinc, between cadmium and nickel, between chromium and manganese, between chromium and nickel, between chromium and lead, between copper and iron, between copper and nickel, between iron and nickel, between iron and lead, and between manganese and nickel: in the case of the spleen between arsonic and mercury, between cadmium and mercury, and between manganese and zinc. 5. The concentrations of arsenic, cadmium, manganese, nickel, and lead in the placentae were higher than these in the organs of the newborn, but the concentrations of copper and iron in the organs of the newborn were higher than those in the placentae. The concentrations of mercury and zinc in the organs of the newborn were higher than those in the placentae, but there was no statistically significant difference between them. And in the case of chromium, there was no difference in concentrations between the placentae and the organs of the newborn.
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https://ymlib.yonsei.ac.kr/catalog/search/book-detail/?cid=CAT000000045607
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