Ascorbic acid가 한진과 발한감소증에 미치는 영향에 관한 실험적 연구

Abstract

[한글]

Study on the Effect of Ascorbic Acid in Miliaria and Hypohydrosis

Kye Eun Cho

Department of Medical Science, Graduate School, Yonsei University

In an attempt to investigate the effective method for the prevention and

treatment of miliaria (prickly heat), ascorbic acid was administered orally to

experimentally produced miliaria and hypohidrosis, and good results were obtained.

There is general agreement that miliaria or prickly heat is associated with

occlusion of the outlets of the eccrine sweat gland but the precise nature of the

actual primary or initiating event is unknown. More over, the only effective

prevention and treatment of miliaria is maintaining the cool environment and the

topical or systemic medications has little common acceptance. Furthermore, these

very common pathological events play a major role in reducing military or

occupational effectiveness of soldiers and workmen who are employed under high

temperature and humidity. There is also no doubt that more effective measures for

the prevention and treatment of prickly heat and hypohidrosis are needed.

Recently, Hindson (1968) reported that ascorbic acid was effective in the

treatment of miliaria.

Miliaris and hypohidrosis were induced by occlusive dressing of one arm with

polyethylene vinyl film for 48 hours in thirty healthy men aged from 22 to 24 year

old.

The effect of prevention and treatment of ascorbic acid in maliaria and

hypohidrosis were observed respectively in two groups, one group which 1gm. of

ascorbic acid was administered daily for seven days and the other a placebo, before

and after inducing miliaria and hypohidrosis.

The following results were obtained.

1. All of the subjects developed miliaria and detectable hypohidrosis after

polyethylene occlusion for 48 hours.

2. Miliaria and hypohidrosis were in proportion but hypohidrosis was persisted

after the disappearance of miliaria.

3. Milaria and hypohidrosis, whatever its mechanism, were tend to be prevented

and treated with ascorbic acid.

From these findings, it is confirmed that ascorbic acid is effective in the

treatment of miliaria as the observation of Hindson.

In addition, ascorbic acid is suggested to be a useful drug for the prevention of

miliaria.

[영문]

In an attempt to investigate the effective method for the prevention and treatment of miliaria (prickly heat), ascorbic acid was administered orally to experimentally produced miliaria and hypohidrosis, and good results were obtained.

There is general agreement that miliaria or prickly heat is associated with occlusion of the outlets of the eccrine sweat gland but the precise nature of the actual primary or initiating event is unknown. More over, the only effective prevention and treatment of miliaria is maintaining the cool environment and the

topical or systemic medications has little common acceptance. Furthermore, these very common pathological events play a major role in reducing military or occupational effectiveness of soldiers and workmen who are employed under high temperature and humidity. There is also no doubt that more effective measures for

the prevention and treatment of prickly heat and hypohidrosis are needed.

Recently, Hindson (1968) reported that ascorbic acid was effective in the treatment of miliaria.

Miliaris and hypohidrosis were induced by occlusive dressing of one arm with polyethylene vinyl film for 48 hours in thirty healthy men aged from 22 to 24 year old.

The effect of prevention and treatment of ascorbic acid in maliaria and hypohidrosis were observed respectively in two groups, one group which 1gm. of ascorbic acid was administered daily for seven days and the other a placebo, before and after inducing miliaria and hypohidrosis.

The following results were obtained.

1. All of the subjects developed miliaria and detectable hypohidrosis after polyethylene occlusion for 48 hours.

2. Miliaria and hypohidrosis were in proportion but hypohidrosis was persisted after the disappearance of miliaria.

3. Milaria and hypohidrosis, whatever its mechanism, were tend to be prevented and treated with ascorbic acid.

From these findings, it is confirmed that ascorbic acid is effective in the treatment of miliaria as the observation of Hindson.

In addition, ascorbic acid is suggested to be a useful drug for the prevention of miliaria.