동상의 예방 및 치료대책에 관한 실험적 연구

Abstract

[한글]

[영문]

Experiments on pathogenesis, prevention and treatment of frostbite were carried out.

Healthy albino rats weighing from 150 to 250 gm for experimental frostbite were employed in this study.

In all experiments, the distal 7 cm tails of rats were immersed directly into ether for 1 minute, which was consistently kept to -20˚C by solid carbon dioxide.

In histopathological observation, the pathologic changes of cold-injured rat tails from the time of exposure to ber time of well developed necrosis are described.

Various drugs were injected into rats intraperitoneally before or after the onset of frostbite, and gross observations concerning the color, ulceration and gangrene which might be developed on affected sites were made for thawing in water on frozen tails of rats.

The results obtained are summarized as follows:

1. he fundamental lesions of frostbite experimentally produced in albino rats are vascular. The formation of agglutinative erythocytic thrombi leads to vascular occlusion and ischemic gangrene.

2. The pretreatment of rats with niacin, vitamin E and Vastulat**(R) were effective for prevention of frostbite, whereas vitamin C was not.

3. The treatment of rats with vitamin C and Vastulat**(R) markedly enhanced the healing of frostbite. However, adinistration of niacin and vitamin E, adn the topical application of local protective ointment were not effective.

4. The effects of both rapid and gradual thawing methods were excellent for the treatment of the frostbite, and of these methods, the former was more superior to the latter.

From these findings, it is suggested that tissue damage in cold-injured rat tail is secondary to vascular change and the rapid thawing in the early treatment of frostbite is the most useful treatment for the alleviation of frostbite.