Clinical outcomes of full-mouth scaling and root planing with locally delivered minocycline in treatment of chronic periodontitis

Abstract

[한글]

[영문]The purpose of this study was to evaluate the clinical effect of locally delivered minocycline in combination with full-mouth scaling and root planing for the treatment of moderate or advanced periodontitis. A total of 40 patients with moderate or severe chronic periodontitis were enrolled to participate in this trial. Plaque index (PI), probing depth (PPD), clinical attachment level (CAL) and bleeding on probing (BOP) were measured at baseline and 4 and 12 weeks after treatment protocol. The test groups had full-mouth scaling and root planing at baseline with the subgingival administration of minocycline ointment, whereas the control group had one-stage scaling and root planing only.PI decreased from the baseline to weeks 4 and 12 after treatment in both groups, but there was no significant difference between the two groups. Both groups had clinical improvement, however, the test group showed greater statistically significant improvement in pocket reduction and attachment gain than the control group. Similarly, both groups also showed significant decreases in BOP, and the BOP reductions at given healing period were statistically significant in the test group. Minocycline used with full-mouth scaling and root planing resulted in statistically significant reduction of probing depth and BOP. Therefore, full-mouth scaling and root planing with locally delivered minocycline were able to achieve satisfactory results in treatment of moderate or advanced periodontitis in a short-term basis.