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Bone formation by escherichia coli-expressed rhBMP-2 using MBCP block carrier in rat calvarial defect and ectopic subcutaneous models
DC Field | Value | Language |
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dc.contributor.author | 소성수 | - |
dc.date.accessioned | 2015-11-21T07:41:19Z | - |
dc.date.available | 2015-11-21T07:41:19Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/124908 | - |
dc.description | Dept. of Dental Science/박사 | - |
dc.description.abstract | [한글] [영문] E.coli-expressed rhBMP-2 (bone morphogenic protein) is currently being studiedas an alternative to mammalian rhBMP-2. MBCP is a useful carrier for BMPs as itsporous structure, low resorption rate, and favorable osteoconductive and bioactiveproperties allow it to serve as a scaffold for bone forming cells.The purpose of thepresent study was to evaluate bone formation by E.coli-derived rhBMP-2 (ErhBMP-2) using a macroporous biphasic calcium phosphate (MBCP) block carrier in a maleSprague-Dawley rat calvarial defect and ectopic subcutaneous models. Rats weredivided into two groups, a MBCP carrier control and a ErhBMP-2/MBCP group andwere evaluated by histologic and histometric analysis following a 2- or 8- weekhealing interval. For the calvarial defect model, enhanced new bone formation wasobserved in ErhBMP-2/MBCP group. For the ectopic subcutaneous model, few newbone formation was evident in the ErhBMP-2/MBCP group. The MBCP block waseffective as a carrier for E.coli-expressed rhBMP-2 for new bone formation, whichwas stably maintained throughout the healing period. The MBCP block system couldprove to be a useful carrier system for tissue engineering using E.coli-expressedrhBMP-2. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Bone formation by escherichia coli-expressed rhBMP-2 using MBCP block carrier in rat calvarial defect and ectopic subcutaneous models | - |
dc.title.alternative | 백서 두개골 결손부와 피부하조직에서, escherichia coli에서 생산된 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | So, Sung Soo | - |
dc.type.local | Dissertation | - |
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