Plaster of Paris가 백서하악골 결손부위의 골회복에 미치는 영향에 관한 조직학적 연구

Abstract

[한글]

Plaster of Paris가 백서하악골 결손부위의 골회복에 미치는 영 향을 연구하기 위하여 저자는 200 gm내외의 백서 (Sprague Dawley Strain) 30마리를 암수 구별없이 대조군 15마리 실험군 15마리로 구분하여 백서하악골 골체부에 소독된 치과용 557번 Bur로 직경 2㎚정도로 우각부를 협설쪽으로 관통하여 골결손을 형성한 후 대조군에는 혈액으로 충만시키고 실험군에는 plaster of Paris 정제를 이식하여 수술 후 제 3, 7, 14, 21, 28일에 각각 회생시켜 광학현미경으로 조직학적 검경을 하여 다음과 같은 결과를 얻었다.

1. 대조군, 실험군 모두 급만성 염증세포의 침윤이 제 3일에 뚜렷하였다.

2. 대조군에서 제1주에 결손부내의 섬유화를 관찰하였고 실험군에서는 섬유화 현상 및 이물반응이 제1주에만 관찰되었다.

3. 골결손부내의 신생골 형성은 대조군, 실험군 모두 제2주부터 관찰되어 제4주에는 완전히 대치되었다.

[영문]

This study was undertaken to evaluate the effect of the plaster of Paris treated on the regeneration of the mandibular bony defect.

30 rats, sprague dawley strain, weighing about 200 gm, were used, devided into control group(15 rats) and experimental group (15 rats).

The mandibular bone was penetrated with dental-grade No. 557 bur about 2mm in diameter buccolingually. In control group the blood was filed in the surgical defect. In experimental group a pellet of plaster of Paris was implanted in the surgical defect. All rats were sacrificed at 3,7,14,21, and 28 days after surgery,

and were examined histologically with light microscope.

The obtained results from this study were as follows:

1. In all of the control group and experimental group, marked acute and chronic inflammatory cells infiltration was found at the third day.

2. In control group fibrosis was found at the first week and in experimental group fibrosis and foreign body reaction was found at the only first week.

3. In all of the control group and experimental group, new bone formation was found at the second week and replaced completely with new bone at the fourth week.