Experimental studies on the effects of thyrold gland to the allergic changes in muscle
Authors
한동환
Issue Date
1961
Description
의학과/박사
Abstract
[한글]
EXPERIMENTAL STUDIES ON THE EFFECTS OF THYROLD GLAND TO THE ALLERGIC CHANGES IN
MUSCLE
DONG HWAN HAN
DEPARTMENT OF PATHOLOGY, YUN-SEI UNIVERSITY, SCHOOL OF MEDICINE
(Director, Prof. Il Sun Yun)
INTRODUCTION:
It is well known that the thyroid gland has profound physiological effects on the
water, chloride, protein, carbohydrate and fat metabolism. Increase, decrease or
cessation of its endocrine function has a great infulence on the various functions
of the body. It has also been known that it partioipates directly or indirectly in
the production of antibody.
Although there have been numerous investigations on the subject of thyroid gland
and also of the allergic reactions, there have been very little available data on
the influence of thyroid gland to the allergic changes produced in the skeletal
muscle. It is the purpose of this paper to report detailed histological changes on
the influence of thyroid gland to the experimentally produced allergic reactions
seen in the skeletal muscle.
MATERIALS AND METHODS.
Healthy albino rabbits weighting around 2 Kg were used. the animals were devided
into 4 groups in the following manner;
1. On group received thyroidectomy.
2. The second group received thyroidectomy and autotransplantation of thyroid
after a certain period of time.
3. The third group of animals received thyroidectomy and later received thyroid
extracts.
4. The fourth group constituted the control group.
The first 3 groups of animals carried each control group accordingly.
Fresh horsed serum was used for antigen. this was injected into the subcutaneous
tissue of rabbits 1.0 c.c. per kg. body weight for four consecutive days. Two weeks
after sensitization, 0.1 c.c. per kg. body weight of serum was again injected into
the muscles of the thigh. Specimen were taken from the sensitized area for
histologic studies in the interval of 3 hours, 6 hours, 12 hours, 24 hours, 48
hours, 72 hours, 1 week and two weeks respectively.
For the second group surgically removed thyroid glands were implanted into the
both sternocleidomastoid muscle. For the third group 0.3 grains per kg. body weight
of thyroid tablet (American Pharmaceutical Company) were given daily for two
consecutive weeks.
RESULTS:
The most prominent, rapid and complicated allergic changes were observed in the
thyroidectomy group, and the less prominent changes in the second group. The least
pronounced changes were observed in the normal control group.
It is the conclusion of this writer that the tyroid gland has a significant
effects on the experimental allergic reactions produced in the skeletal muscle and
that it has a definite inhibitory action.
[영문]
It is well known that the thyroid gland has profound physiological effects on the water, chloride, protein, carbohydrate and fat metabolism. Increase, decrease or cessation of its endocrine function has a great infulence on the various functions of the body. It has also been known that it partioipates directly or indirectly in the production of antibody.
Although there have been numerous investigations on the subject of thyroid gland and also of the allergic reactions, there have been very little available data on the influence of thyroid gland to the allergic changes produced in the skeletal muscle. It is the purpose of this paper to report detailed histological changes on the influence of thyroid gland to the experimentally produced allergic reactions seen in the skeletal muscle.
MATERIALS AND METHODS.
Healthy albino rabbits weighting around 2 Kg were used. the animals were devided into 4 groups in the following manner;
1. On group received thyroidectomy.
2. The second group received thyroidectomy and autotransplantation of thyroid after a certain period of time.
3. The third group of animals received thyroidectomy and later received thyroid extracts.
4. The fourth group constituted the control group.
The first 3 groups of animals carried each control group accordingly.
Fresh horsed serum was used for antigen. this was injected into the subcutaneous tissue of rabbits 1.0 c.c. per kg. body weight for four consecutive days. Two weeks after sensitization, 0.1 c.c. per kg. body weight of serum was again injected into
the muscles of the thigh. Specimen were taken from the sensitized area for histologic studies in the interval of 3 hours, 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, 1 week and two weeks respectively.
For the second group surgically removed thyroid glands were implanted into the both sternocleidomastoid muscle. For the third group 0.3 grains per kg. body weight of thyroid tablet (American Pharmaceutical Company) were given daily for two consecutive weeks.
RESULTS:
The most prominent, rapid and complicated allergic changes were observed in the thyroidectomy group, and the less prominent changes in the second group. The least pronounced changes were observed in the normal control group.
It is the conclusion of this writer that the tyroid gland has a significant effects on the experimental allergic reactions produced in the skeletal muscle and that it has a definite inhibitory action.