한국산 다람쥐 접종에 의한 비뇨생식기 결핵환자의 요중결핵균검출에 관한 연구

Abstract

[한글]

A STUDY OF THE ISOLATION OF TUBERCLE BACILLI FROM THE PATIENT'S URINE WITH

GENITOURINARY TUBERCULOSIS BY THE INOCULATION INTO THE KOREAN CHIPMUNKS(TAMIAS,

SIBIRICUS ASIATIUS, GMELIN)

HYUNG KI CHOI

Department of Medical Science The Graduate School Yonsei University

(Directed by professor Chong Soon Wang)

The detection of the tubercle bacilli is absolutely necessary to make definite

diagnosis of patients with genitourinary tuberculosis. Recently it has been

reported that the detection rate of tubercle bacilli from the patient's urine is

decreasing because of abuse of the anti-tuberculous drugs and the resistance

developed in the experimental animals such as mouse and guinea pig (Marks, 1972).

Therefore the necessity of the development of better diagnostic method has been

mandatory. Recently it was reported that the korean chipmunks(Tamias sibiricus

asiaticus, Gmelin) are highly susceptible to tubercle bacilli (Chang et al., 1971).

The specific objection of this study is to persue the possibility of using the

chipmunks for the early diagnosis of genitourinary tuberculosis.

Twenty-four hour urines of 34 patients with suspected genitourinary tuberculosis

were tested for tubercle bacilli with smear, culture, and inoculation into

chipmunks and mice intraperitoneally.

The results are briefly summarized as follows:

1. 18 cases out of 34 patients with suspected genitourinary tuberculosis were

confirmed to be positive by any means of stained smear, culture and animal

inoculation. Of 18 proved genitourinary tuberculosis, 12 cases were confirmed by

smear, culture and mouse inoculation.

2. In the group of chipmunks inoculation, 8cases were found to be positive on the

10th day and 14 cases on the 20th day.

3. These findings suggest that the period required for the detection of tubercle

bacilli was shorter and the positive rate was higher than that of other animals and

other methods. For the clinical applications of the Korean chipmunks as a

diagnostic tools, further effort is considered to be necessary.

[영문]

The detection of the tubercle bacilli is absolutely necessary to make definite diagnosis of patients with genitourinary tuberculosis. Recently it has been reported that the detection rate of tubercle bacilli from the patient's urine is decreasing because of abuse of the anti-tuberculous drugs and the resistance

developed in the experimental animals such as mouse and guinea pig (Marks, 1972).

Therefore the necessity of the development of better diagnostic method has been mandatory. Recently it was reported that the korean chipmunks(Tamias sibiricus asiaticus, Gmelin) are highly susceptible to tubercle bacilli (Chang et al., 1971).

The specific objection of this study is to persue the possibility of using the chipmunks for the early diagnosis of genitourinary tuberculosis.

Twenty-four hour urines of 34 patients with suspected genitourinary tuberculosis were tested for tubercle bacilli with smear, culture, and inoculation into chipmunks and mice intraperitoneally.

The results are briefly summarized as follows:

1. 18 cases out of 34 patients with suspected genitourinary tuberculosis were confirmed to be positive by any means of stained smear, culture and animal inoculation. Of 18 proved genitourinary tuberculosis, 12 cases were confirmed by smear, culture and mouse inoculation.

2. In the group of chipmunks inoculation, 8cases were found to be positive on the 10th day and 14 cases on the 20th day.

3. These findings suggest that the period required for the detection of tubercle bacilli was shorter and the positive rate was higher than that of other animals and other methods. For the clinical applications of the Korean chipmunks as a diagnostic tools, further effort is considered to be necessary.