한국 신생아 갑상선 홀몬분비 양상에 관한 연구

Abstract

[한글]

선천성 갑상선 기능 저하증의 발생빈도는 약 7,000명 중 1명(Hobel, 1980)으로 보고되었다. 이로 인해 지능발육부전(mental retardation)이 초래되나 조기발견으로 치유가 가능하다. 이에 본 저자는 한국에서 처음으로 신생아의 갑상선 홀몬 분비 양상을 연구할 목적으로 1980년 11월부터 동년 12월까지 연세대학교 의과대학 부속 세브란스 및 제일병원 산부인과에서 출생한 생후 3일에서 7일 사이의 신생아 79명을 대상으로 하여 최근 새로이 개발된 특이도(specificity) 및 민감도(sensiticity)가 우수한 방사면역측정법(radioimmunoassay)에 의하여 혈청내 T^^4(Thyroxin) 및 TSH(Thyrotropin)치를 측정하여 다음과 같은 결과를 얻었다.

1. 신생아 T^^4의 평균치는 9.44±0.29 ㎍/100㎖를 나타내었으며 9.0∼10.9㎍/100㎖ 범위에 속하는 신생아가 43명(54.4%)으로 가장 높은 분포를 보였다.

2. 신생아 TSH의 평균치는 4.23±1.56μIU/㎖를 나타내었으며 2.0∼2.9μIU/㎖ 범위에 속하는 신생아가 24명(30.3%)으로 가장 높은 분포를 보였다.

3. 신생아의 성별T^^4, TSH의 평균치를 비교하여 볼 때 통계학적으로 유의한 차이는 없었다.

4. 신생아의 혈청 T^^4, TSH의 평균치를 체중에 따라 비교하여 볼 때 통계학적으로 유의한 차이를 볼 수 없었다.

A Study on the Serum T^^4 (thyroxine) and TSH (thyrotropine) Values in Korean

Neonates

Kwang Yul Cha, M.D.

Department of Medical Science, The Graduate School, Yonsei University

(Directed by Professor Hyun Mo Kwak,M.D.)

The incidence of congenital hypothyroidism is about 1 in 7,000 (Hobel, 1980) and

it is believed to be an cause of the mental retaidation: Early diagnosis and

treatment of congenital hypothyroidism is critical to the prevention of severe

mental retardiation.

Thus, there is a need for further study and improvement in screening tests of

hypothyroidism.

This study was conducted to evaluate values of serum T^^4 and TSH in Korean

neonates at the age of 3-7 days.

Seventy-nine neonates were recruited from Department of Obstetrics and

Gynecology, Yonsei University College of Medicine and Jeil Hospital.

Serum T^^4 and TSH values were measured by specific and sensitive

radioimmunoassay.

Results obtained are as followes:

1. The average T^^4 value was 9.44 ± 0.29 ug/100ml. T^^4 values obtained from 43

neonates (54.4% of the total sample population) were in 9.0 - 10.9 ug/100ml, which

was highest distribution of neonates.

2. The average TSH value was 4.238 ± 1.56 uIU/ml. TSH values obtained from 24

neonates (30.3% of total sample population) were in 2.0 - 2.9 uIU/mI, which was

highest distribution of neonates.

3. There was no sex differences in serum T^^4 and TSH values in male and female

neonates.

4. No significant correlation was observed between birth weight and serum T^^4

and TSH values in Korean neonates.

It might be, therefore, concluded that serum levels of T^^4 ans TSH in 3-7 days

old Korean neonates were not significantly different from normal values of Korean

adult and there were no sex and birthe weight differences in serum T^^4 TSH of

Korean neonates.

[영문]

The incidence of congenital hypothyroidism is about 1 in 7,000 (Hobel, 1980) and it is believed to be an cause of the mental retaidation: Early diagnosis and treatment of congenital hypothyroidism is critical to the prevention of severe

mental retardiation.

Thus, there is a need for further study and improvement in screening tests of hypothyroidism.

This study was conducted to evaluate values of serum T^^4 and TSH in Korean neonates at the age of 3-7 days.

Seventy-nine neonates were recruited from Department of Obstetrics and Gynecology, Yonsei University College of Medicine and Jeil Hospital.

Serum T^^4 and TSH values were measured by specific and sensitive radioimmunoassay.

Results obtained are as followes:

1. The average T^^4 value was 9.44 ± 0.29 ug/100ml. T^^4 values obtained from 43 neonates (54.4% of the total sample population) were in 9.0 - 10.9 ug/100ml, which was highest distribution of neonates.

2. The average TSH value was 4.238 ± 1.56 uIU/ml. TSH values obtained from 24 neonates (30.3% of total sample population) were in 2.0 - 2.9 uIU/mI, which was highest distribution of neonates.

3. There was no sex differences in serum T^^4 and TSH values in male and female neonates.

4. No significant correlation was observed between birth weight and serum T^^4 and TSH values in Korean neonates.

It might be, therefore, concluded that serum levels of T^^4 ans TSH in 3-7 days old Korean neonates were not significantly different from normal values of Korean adult and there were no sex and birthe weight differences in serum T^^4 TSH of

Korean neonates.