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Candida stellatoidea의 분리감소 확인을 위한 Candida 분리주의 재검토

Other Titles
 Examination fo candida isolates to verify decreased isolation of candida stellatoidea 
Issue Date
1991
Description
보건학과/석사
Abstract
[한글] C. stellatoidea는 비뇨생식기에서 흔히 분리되며 감염을 일으키던 진균이다. 이 진균의 분리가 Mexico나 Nigeria에서도 근년에도 드물지 않으나, 미국에서는 현저하게 드물어졌는데 그 감소는 개인위생의 개선때문으로 추측되고 있다. 이 진균은 여러 성상의 유상성 때문에 C. alnicans 로 분류하자는 주장이 있고, 임상검사실에서는 균종을 구별하지 않아 우리나라에서의 C. stellatoidea 분리 현황은 알 수 었다. 이 진균을 통상으로 C. albicans 와 감별할 필요는 없다하더라도, 어떤 균종의 미생물이 시기와 지역에 따라서 증감되는 것을 밝히는 일은 감염병 이해에 필요하다고 하겠다. 이에 이 연구에서는 우리나라에 있어서의 C. stellatoidea의 분리현황을 밝히고자 1990년 10월 -1991년 3월에 원주기독병원 환자의 비뇨생식기 검체에서 분리되는 Candida 균종을 발아관 및 후막포자시험, 탄수화물 발효 및 동화시험등으로 동정하였으며, 또한 신촌 세브란스병원과 원주기독병원 환자에서 분리되어 C. albicans로 동정된 균주중에 C. stellatoidea가 포함되어 있는지를 시험하여 다음과 같은 결론을 얻었다. 1. 비뇨생식기 검체에서의 Candida의 분리율은 신촌세브란스병원 환자에서 0.61%, 원주기독병원 환자에서 1.37%로 평균 1.36%이었다. 2. 원주기독병원 환자에서 분리한 Candida 중 C. albicans는 39.4%, C.trolicalis는 22.9%로 이들이 대부분을 차지하였고, C. stellatoidea는 분리되지 않았다. 3, 신촌세브란스 병원과 원주 기독병원에서 C. albicans로 예비동정된 56 균주를 재시험한 바 자당동화 음성이어서 C.stellatoidea로 해석되는 균주는 없었다. 본 연구에서는 많은 균주를 시험하지는 못하였으므로 더 다양한 대상군에서의 광범위한 연구가 필요하지만, C. stellatoidea가 전혀 분리되지 않은 것은 이 진균이 우리나라 사람의 비뇨생식기에 드문 것이 확실함을 보인것이라는 결론을 얻었다. Examination of Candida isolates to verify decreased isolation of Candida stellatoidea Yoon Kyung Jo Graduate School of Health Science and Management, Yonsei University (Directed by Professor Samuel Y. Lee, M.D.) Candida stellatoidea a species of fungus, used to be frequently isolated from genitourinary specimen. In America, much decreased isolation of the organism was reported recently, while the decrease was not so obvious in other countries such as Mexico and Nigeria. The decrease was considered due to the improved personal hygine. C.stellatoidea has many smilarities and are often suggested to be included to the species C.albicans. The isolation rate of C. stellatoidea is not known in Korea as they are not differentiated in routine Laboratories. Finding the trend of isolation of C.stellatoidea may add our understanding of some of the principles of infectious diseases. The purpose of this study was to determine the current status of C. stellatoidea isolation in Korea. Species of urogenital isolates of Candida from patients at Wonju Christial Hospital were determined by tests of germ tube, chlamydospore, carbohydrate fermentation and assimilation. The strains identified as C. albincans at Severance Hospital and Wonju Christial Hospital were reexamined for their possibility of beeing C. stellatoidea. The following results were obtained. 1. The isolation rates of Candida species from urogenital specimens were 0.61% at Severance Hospital and 1.37% at Wonju Christial Hospital, with mean rate of 1.36%. 2. At the Wonju Christial Hospital more frequently isolated Candida species were C. albicans and C. tropicalis, 39.4% and 22.9%, respectively. C. stellatoidea was not isolated 3. All of the 56 isolateds of Candida, presumptively identified as C.albicans at both hospitals, were wucrose assimilation positive, suggertion none are C. stellatoidea. It is concluded that none existence of C. stellatoidea among the clinical isolated of Candida in this study indicate rarity of the species in the urogenital specimens of Koreans, although more extensive study may be required.
[영문] Candida stellatoidea a species of fungus, used to be frequently isolated from genitourinary specimen. In America, much decreased isolation of the organism was reported recently, while the decrease was not so obvious in other countries such as Mexico and Nigeria. The decrease was considered due to the improved personal hygine. C.stellatoidea has many smilarities and are often suggested to be included to the species C.albicans. The isolation rate of C. stellatoidea is not known in Korea as they are not differentiated in routine Laboratories. Finding the trend of isolation of C.stellatoidea may add our understanding of some of the principles of infectious diseases. The purpose of this study was to determine the current status of C. stellatoidea isolation in Korea. Species of urogenital isolates of Candida from patients at Wonju Christial Hospital were determined by tests of germ tube, chlamydospore, carbohydrate fermentation and assimilation. The strains identified as C. albincans at Severance Hospital and Wonju Christial Hospital were reexamined for their possibility of beeing C. stellatoidea. The following results were obtained. 1. The isolation rates of Candida species from urogenital specimens were 0.61% at Severance Hospital and 1.37% at Wonju Christial Hospital, with mean rate of 1.36%. 2. At the Wonju Christial Hospital more frequently isolated Candida species were C. albicans and C. tropicalis, 39.4% and 22.9%, respectively. C. stellatoidea was not isolated 3. All of the 56 isolateds of Candida, presumptively identified as C.albicans at both hospitals, were wucrose assimilation positive, suggertion none are C. stellatoidea. It is concluded that none existence of C. stellatoidea among the clinical isolated of Candida in this study indicate rarity of the species in the urogenital specimens of Koreans, although more extensive study may be required.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/117053
Appears in Collections:
2. 학위논문 > 4. Graduate School of Public Health (보건대학원) > 석사
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