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치근단 병소에서 면역적격세포의 분포에 관한 연구

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dc.contributor.author윤태철-
dc.date.accessioned2015-11-20T05:12:07Z-
dc.date.available2015-11-20T05:12:07Z-
dc.date.issued1992-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/116362-
dc.description치의학과/박사-
dc.description.abstract[한글] 치근단 병소는 근관내의 유해자극성 물질에 의하여 발생하며, 이 유해물질을 제거하고 근관을 밀폐함으로서 치근단 병소의 치유를 유도하기 위하여 근관치료를 시행한다. 치근단병소에는 면역학적 반응이 관여하는 것으로 알려져 있으며, 치근단 병소내에는 여러가 지 면역적격세포가 분포되어 있다. 이에 저자는 근관치료의 각 단계에서 생검된 94 예의 치근단병소내의 면역적격세포의 분포를 면역조직화학적 방법으로 연구 관찰하여, 다음과 같은 결론을 얻었다. 1. 모든 치근단병소에는 T임파구. 형질세포, B임파구, 대식세포가 침윤되어 있었고, T임파구가 가장 많이 침윤되어 있었으며, B임파구와 대식세포는 T임파구나 형질세포에 비하여 적게 침윤되어 있었다(P<0.05 : Oneway ANOVA test). 2. 모든 치근단 병소의 미처치군과 근관세척 및 확대군에서는 T보조자임파구가 가장 많이 침윤되어 있었다(P>0.05 Oneway ANOVA test). 3. 치근단 농양, 치근단 육아종, 만성염증 및 섬유화 병소의 근관충전군에서는 형질세포가 가장 많이 침윤되어 있었으나, 치근단 낭종의 근관충전군에는 T보조자임파구가 가장 많이 침윤되어있다(P>0.05 Oneway ANOVA test) . 이상의 소견을 종합하여 보면, 치근단 농양, 치근단 육아종, 만성염증 및 섬유화 병소. 치근단 낭종에는 면역학적 반응이 관여하며, 근관충전후에는 면역적격세포의 분포에 변화가 일어남으로 보아, 근관치료에 의하여 치근단 병소에 작용하는 면역반응에 변화가 일어난다고 사료된다. [영문] Periapical lesions are developed as a result of inflammatory response to irritants from root canal system. Clinicians remove these irritants from root canal system and seal the root canal space to induce healing of the periapical lesions. Immunopathologic responses may play an important role in development and progression of periapical lesions and periapical lesions contain immunocompetent cells. The purposes of the present study were to analys and to compare the distribution of the immunocompetent cells in the human periapical lesions according to the stage of endodontic treatment using indirect immunoperoxdase technique. Obtained 94 human periapical lesions were devided into four groups : Group 1 : no endodontic treatment(28 samples) Group 2 : root canal enlarged and irrigated(28 samples) Group 3 : root canal 1i13e4(29 samples) Group 4 : unknown(9 samples) Monoclonal antibodies to examine target cells were UCHL-1 for T lymphocytes(1 : 200, Dakopatt, Denmark), L26 for B lymphocytes(1 : 200, Dakopatt, Denmark), OPD4 for helper T lymphocytes(1 :200, Dakopatt, Denmark) and alpha-1-antichymotrypsin for macrophages(1 : 2000, Dakopatt Den-mark). The following results were obtained : 1. All the periapical lesions studied were infiltrated by T lymphocytes, plasma cells,3 lymphocytes, and macrophages. T lymphocytes were more infiltrated than 8 lymphocytes, and B lymphocytes and macrophages were less infiltrated than T lymphocytes and plasma cells(P(0.05 : Oneway ANOVA test). 2. In untreated group and canal irrigated and enlarged group of all the periapical lesions, helper T lymphocytes were predominently infiltrated(P〉0.05 :Oneway ANOVA test). 3. In canal filled groups of all lesions except periapical cyst plasma cells were predominently infiltrated. But, in canal filled group of periapical cyst, helper T lymphocytes were the predominent cells(P〉0.05 : Oneway ANOVA test). The above results shows that the immunologic responses play important role in pathogenesis of periapical lesions and the immunologic response involved undergoes certain changes after endodontic therapy.-
dc.description.statementOfResponsibilityrestriction-
dc.publisher연세대학교 대학원-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title치근단 병소에서 면역적격세포의 분포에 관한 연구-
dc.title.alternative(A) quantitative analysis of the immunocompetent cells in periapical lesions of the human teeth-
dc.typeThesis-
dc.identifier.urlhttps://ymlib.yonsei.ac.kr/catalog/search/book-detail/?cid=CAT000000007687-
dc.contributor.alternativeNameYoon, Tai Cheol-
dc.type.localDissertation-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 3. Dissertation

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