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DDS 약물로 인한 메트헤모글로빈 혈증에 관한 임상적 연구

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dc.contributor.author어희선-
dc.date.accessioned2015-11-20T05:06:31Z-
dc.date.available2015-11-20T05:06:31Z-
dc.date.issued1982-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/116145-
dc.description의학과/석사-
dc.description.abstract[한글] 1977년 1월부터 1981년 6월까지 4년 6개월동안 원주기독병원 소아과에서 경험한 57예의 DDS약물로 인한 메트헤모글로빈혈증 환자에 대해 발생빈도, 복용동기, 임상소견, 검사소견 및 입원기간등을 종합분석하였다. 연령별 분포는 6세 이전의 소아에서 90%가 발생하였 고 복용동기는 대부분이 우발사고이었다. 주증상으로는 청색증이 57예전예에서 나타났으며 복용후 12시간내에 약 90%에서 청색증을 보였으며 DDS 25mg(1정)을 복용한 경우도 있었다. 복용량과 메트헤모글로빈치의 관계는 일정한 비례적인 관계는 없었으며 중증 빈혈을 보인 경우는 없었고 사망한 경우도 없었다. 입원기간은 약 3분의 2가 3일이내이었다. 치료는 체중 kg당 methylene blue 1∼2mg을 3분내에 정맥주사하였으며 예방은 DDS의 남용을 막도록 주민들을 계몽하는 것이 좋을 것으로 사료된다. [영문] Various compounds activate the oxidation of hemoglobin. These include nitrites, sulfonamides, aniline derivatives, chlorates, quinones, acetanilid and phenacetin. The striking offender has been DDS in infancy and childhood who live in Kangwon Do, Korea. The common untoward effects of DDS are hemolytic anemia and methemoglobinemia. This clinical study was carried out for analysis on 57 cases which were diagnosed as DDS induced methemoglobinemia at the department of pediatrics in Wonju Christian Hospital during 4 years and 6 months, from Jan. 1, 1977 to June 30, 1981. The results were as follows; 1. DDS induced methemoglobinemia developed in 57 cases among 129 cases of total drug intoxication. 2. The intoxication showed the highest incidence in children before 6 year of age. 3. The dosage ingested was from 25 mg to 250 mg in 32 cases, but others were unknown. 4. Cyanosis occurred in all cases. 5. The duration between DDS poisoning and the onset of symptoms was within 6 hours in 60% of cases. 6. Any case did not show profound anemia. 7. The correlation coefficient was 0.6 between the dosage and the methemoglobin level.-
dc.description.statementOfResponsibilityrestriction-
dc.publisher연세대학교 대학원-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDDS 약물로 인한 메트헤모글로빈 혈증에 관한 임상적 연구-
dc.title.alternativeClinical observation of DDS induced methemoglobinemia-
dc.typeThesis-
dc.identifier.urlhttps://ymlib.yonsei.ac.kr/catalog/search/book-detail/?cid=CAT000000003294-
dc.contributor.alternativeNameAuh, Hee Seon-
dc.type.localThesis-
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 2. Thesis

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