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고환이 관절낭의 allergy성 변화에 미치는 영향에 관한 실험적 연구

Other Titles
 (The) experimental studies of the influences of the testis upon the allergic changes of the joint-capsule 
Authors
 문이복 
Issue Date
1961
Description
의학과/박사
Abstract
[한글]
[영문] There have been numerous investigations and reports concerning effects of endocrine organs on experimental allergic reactions of various organs. However, reported results have been variable in many respects and sometimes caused certain confusions. This investigation deals with an experimental study of allergic inflammation produced in joint-capsule and to study effects of testis and its hormone upon such inflammations. MATERIALS AND METHODS Healthy male albino rabbits weighing around 2㎏ were used. The animals were fed with an ordinary diet consisted of bean curd and supplemented with vegetable pieces. The antigen employed was fresh horse serum prepared by the laboratory of the National Bureau of Preventive Medicine. The testosterone utilized was Testoviron made by Schering AG of Berlin, West Germany. The animals were divided into six groups as the following: 1. Normal control group 2. Animals with orchidectmony 3. Animals with orchidectmony and also auto-transplantations of testis into the thigh muscles. 4. Animals with orchidectmony and receiving intramuscular infection of testosterone. 5. Animals with homo-transplantation of testis into the thigh muscles. 6. Animals receiving testosterone injection Each group of animals received two sets of experimentations. One set of experiment consisted of initial sensitization by horse serum given subcutaneously 1.0 cc per ㎏ body weight every other day for four times. After two weeks from the completion of the initial sensitization, 0.1 cc per ㎏ body weight of horse serum was injected into the joint capsule 0.1 cc per ㎏ body weight. After the completion of injections, animals were sacrificed at regular intervals of 3 hours, 6 hours, 12 hours 24 hours, 48 hours, 72 hours, one week and 2 weeks respectively. Air embolism was exclusively used for the method of sacrifice. Proper amount of joint capsule was resected and fixed in 10% neutral formalin and stained with hematoxylin & eosin and Van-Gieson Stains. RESULTS AND SUMMARY 1. Experimental allergic inflammation has been produced in the joint capsule of joint capsule of albino rabbits by using horse serum as antigen and an attempt has been made to investigate the effects of testis and testicular hormone upon such inflammations. 2. Careful histological analysis reveals the intensity of inflammatory reaction to be in the order of a). animals receiving testosterone injection, b). animals with homo-transplantation of testis, c). normal control group, d). animals with orchidectomy and receiving testosterone, e). animals with orchidectomy and receiving auto-transplantation of testis and f) animals with orchidectomy and respectively. 3. From the results obtained by above experiments, it is the opinion of this investigator that the testis and testicular hormones definitely enhance experimental allergic inflammation of joint capsule.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/115758
Appears in Collections:
2. Thesis / Dissertation (학위논문) > 1. College of Medicine (의과대학) > Ph.D. (박사)
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https://ymlib.yonsei.ac.kr/catalog/search/book-detail/?cid=CAT000000004263
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