한국인의 이비인후종양에 관한 임상 및 병리조직학적 고찰

Abstract

[한글]

[영문]

Malignant tumors became to have more and more interest in both for basic

researchers and clinicians, because most inflammatory diseases which had threatened

our livelihood in the past are under control with antibiotics.

Clinically, the neoplastic lesions of the oto-rhino-laryngological field are

detected early for their earlier symptoms and external visibility. Moreover, the

anatomical and histological characteristics such as the thin wall of the paranasal

sinuses with wide continuity, and intimate contact of mucosa or skin to underlying

cartilage on anterior nasal septum, nasal alae, epiglottis and larynx give the

adequate condition to spread the neoplastic lesions early, rapidly and widely. And

other anatomic factors such as: (1) pilosebacious elements of the nares, (2) mucous

gland, abundant vascular tissue, and the nerve elements of nasal cavity, (3) mucous

gland, abundant lymphoid tissue, and possible embryonal remnants in the pharynx,

(4) simple squamous mucosa of oropharynx and tonsils, (5) glands of epiglottis,

larynx, trachea also influenced the special characteristics and peculiar behaviors

of the oto-rhino-laryngeal tumors.

With the development of irradiation therapy and chemotherapy including surgical

technic, there have been great advance of anticancer therapy, and we are highly

expecting to solve this problem as like for anti-inflammatory in a near future. To

solve this problem, it is required to have sound knowledge about clinical and

histopathological characters of the tumors as much as the knowledge of therapeutic

measures.

Although a lot of reports have been made public about the tumors of

oto-rhino-laryngological field in Korea and foreign countries, still there have

leaved something to be desired about the general realities and actural condition,

and most of these were confined to only one organ or the period handled the cases

was short.

So the auther studied the clinical and histopath logical analysis of tumors of

oto-rhino-laryngological field which were confirmed by biopsy during last twelve

and a half years in Severance hospital.

Materials and Methods.

The materials used in this study consist of biopsy tissues from

oto-rhino-laryngological field under the suspicion of new growth or inflammatory

lesions during last twelve and a half years from Jan. 1960 to Jun. 1972.

All specimens were fixed in 10% formalin, and dehydrated with graded alcohol, and

next embedded in paraffin.

The paraffin embedded blocks were cut in 5-6u thickness and sections were stained

by the Hematoxylin-Eosin method. Clinical analysis including age, sex, chief

complaint and duration of illness were done with available charts.

Histopathological studies on all biopsy cases were performed with the following

categories.:

+-Epithelial

+-----Malignant--------------------------+-Mesenchyma

Tumors ---+ +-Unclassified

+-----Neoplastic ------+----Epithelial

+-----Benign----+ +----Mesenchymal

+-----Non-neoplastic

Inflammations

Others(Non pathologic, and insufficient materials)

Results and Summary.

Clinical and histopathological studies were made on 1758 biopsy tissues of

oto-rhino-laryngological lesions which were submitted to the department of

pathology, Yonsei University college of Medicine, during the period of twelve and a

half years from Jan. 1960 to Jun. 1972.

The following results were obtained.

1. Among 1758 cases of biopsy, tumors: 1060(60.3%). inflammations: 639(36.3%),

and others: 59(3.4%). In tumors, benign tumors: 526(47.7%) and malignant tumors:

534(52.3%).

2. The mean age for benign tumors was 38.1 and for malignant tumors, 52.4. which

showes somewhat earlier tendency to tumor age than foreigners.

3. The male to female ratio were 2.2;1 for benign tumors and 3.2;1 for malignant

tumors, showing male preponderance in both.

4. In the clinical data, hoarseness was the most frequen chief complaint for

laryngeal tumors, nasal obstruction for nasal and paranasal tumors, palpable

cervical mass and nasal obstruction for pharyngeal tumors, and oral and cervical

mass for oral tumors.

5. The duration of illness were less than on year in 60.2% of benign tumors and

83.8% of malignant tumors.

6. The most common histopathological type of benign non-neoplastic tumors was

polyp with the incidence of 89.3% of those.

7. The most common histopathological type of benign neoplastic tumors was

papilloma with the incidence of 53.2% and then in order of frequency was

angiofibroma, hemangioma, and mixed tumor ectc.

8. The most common histopathological type of malignant tumors was squamous cell

carcinoma with the incidence of 69.8% (363/534) and then in order of frequency was

malignant lymphoma, anaplastic carcinoma, basal cell carcinoma etc.

9. The clinical and histopathological analysis for aural lesions was inavailable

because of the data size.