저온과 5%포도당액충전을 이용한 체외순환에 관한 실험적 연구

Abstract

[한글]

[영문]

A hypothermic, low flow perfusion, utilising 5% dextrose in water as the priming

fluid in the pump-oxygenater, was carried out to observe changes in oxygen

consumption, blood pH and CO^^2 tension during the bypass period.

The heat transfer efficiency of our own device was fairly satisfactory as

compared which that of the other authors.

A low oxygen consumption which was approximately one third of the preperfusion

value, was observed during the total bypass period. This is believed to be due to

the effect of low flow rates employed, hypothermia and low CO^^2 tension observed

in these animals. In two animals, it was observed that the oxygen consumption

increased with the increase of perfusion flow rates. In principle, the oxygen

uptake of an organism may be expected to remain constant over a wide range of

perfusion flow rates, as long as the tissuessean extract whatever oxygen they need.

However, many experimental findings indicate a decrease in oxygen uptake with

decreasing perfusion rates. It appears that during periods of decreased oxygen

supply the perfused organism lives partly under anaerobic conditions and incurs an

oxygen debt which must be paid back at a later time. This was observed in these

animal showing markedly increased oxygen consumption at the postperfusion period

which reached about 150% of preperfusion value.

The pH of the arterial blood and the partition of the total CO^^2 remained within

a fairly normal range. There was marked reduction in CO^^2 tension during the

bypass period which was mainly due to the hyperventilation at the preperfusion

period. Its harmful effect on the oxyhemoglobin dissociation curve and cerebral was

discussed.

The hemodilution by the use of 5% dextrose in water as the priming fluid is

considered not only insignificant as far as the oxygen carrying capacity of the

blood is concerned but also has many advantages. The hemoglobin value which was

moderately low during bypass returned to 92% of the preperfusion figure after the

bypass, indicating that most of the added fluid was not available to the

circulation oxygenater was returned to the animal.