Dexamethasone 및 수종약물이 Shope rabbit papilloma에 미치는 영향

Abstract

[한글]

[영문]

In 1933 Shope described an infectious papilloma of wild cottontail rabbits. Shope

rabbit papilloma is a virus-induced epidermal neoplasm indigenous to western

cottontail rabbits and readily transmissible to domestic rabbits by inoculation

with a cell-free extract of wild cottontail papilloma. Shope papilloma induced in

the domestic rabbits may spontaneously, remain benign, or progress to carcinoma.

Kidd et al. (1936) noted that the regression is not correlated with the titer of

virus neutralizing antibody. The possibility that papilloma regression is brought

about by a mechanism analogous to that operating in allograft rejection was

suggested by kidd et al. (1938) with the view of the histological resemblance

between papilloma regression and rejection of allografted tissue. That regression

is mediated by an immu mechanism is strongly indicated by the findings of Evans et

al.(1962) that the proportion of rabbits showing regression is substantially

increased by vaccination of rabbits with rheir own papilloma tissue or with

papilloma tissue from another rabbits.

Mcmichael (1967) demonstrated that suppression of regression was achieved by use

of large doses of corticosteroid.

The effect of 5-fluorouracil on human warts was mentioned as being effective by

Goldman et al.(1963).

In Korea resinous extract from Paulownia coreana has long been used empirically

in the treatment of human warts.

In this investigation effects of dexamethesone administration on the development

and the spontaneous regression of Shope papilloma in domestic rabbits were studied.

At the same time, observations were made to evaluate the comparative

effectiveness of topical application of 5% 5-fluorouracil ointment resinous extract

from Paulownia cireana on Shope papilloma in the domestic rabbits.

The results are summarized as follows :

1. Administration of dexamethasone significantly reduced the spontaneous

regression of Shope papilloma in donestic rabbits by 12 weeks after virus

inoculation.

2. Topical application of 5% 5-fluorouracil ointment on Shope papilloma cured the

tumors by 4 weeks of drug application. However, similar treatment with resinous

extract from Paulownia coreana was without any demonstrable effects.

3. Marked losses of body weight became manifest in dexamethasone treated rabbits.

4. Reinoculation of Shope papilloma virus into 2 rabbits whose papilloma had

regressed 3 months ago failed to produce papillomas.