가토 안압에 있어서의 간접반응에 관한 연구

Abstract

[한글]

본 실험은 가토 안압에 있어서의 간접반응의 실재여부와 발생에 관한 관찰을 목적으로

하였다.

실험동물로 유색 웅성가토 28마리를 군으로 분류하여 각 군에 따라 각각 일정한 시간에

국소점안마취하에서 (0.5% tetracaine hydrochloride) Mueller electronic tonometer를

사용하여 안압을 측정하였다. 또한 각 군에 따라 압박과 구호마취를 다음과 같이 하였다.

실험군 ①: 실험시작후 56분부터 60분까지 2분간, Baillart ophthalmodynamometer를 사

용하여 50gm의 무게로 우안을 압박하였다.

실험군 ②: 실험시작후 약 60분경에 2% procaine hydroehloride 1.0CC를 우안에 구후주

사를 하였다. Epinephrine을 사용하지 않았으며 주사후 맛사지도 하지 않았다.

실험군 ③ 실험시작후 약 40분경에 우안에 구후마취를 하였고 86분부터 90분까지 4분간

, 상술한 방법으로 우안을 압박하였다.

각 군의 실험성적은 t-test에 의하여 통계학적으로 유의성을 검토하였으며 다음과 같은

결과를 얻었다.

1. 우안에 50gm의 무게로 4분간 압박하였을 때 우안의 안압은 하강하였다가 상승함을

관찰하였으며 좌안에서는 간접반응으로 안압이 하강하는 것을 보았다.

2. 우안에 2% porcaine phydrochloride, 1.0cc로 구후마취를 하면 우안의 안압은 하강

하였는데 좌안의 안압은 상승하였다.

3. 우안의 구후마취후 안안에 압박을 가하면 우안의 안압 상승도는 우안 구후마취를 하

지 않은 경우보다 낮은 것을 보았다.

좌안의 안압에 있어서는 간접반응이 나타나지 않았으며 이는 우안 구후마취로 인하여

이 반응의 원심로가 차단된 것으로 볼 수 있다.

4. 좌안에 구후마취후 우안에 압박을 가하면 우안의 안압 상승도는 좌안 구후마취를 하

지 않은 경우와 비슷하였다. 좌안의 안압에 있어서는 간접반응이 나타나지 않았으며 이는

좌안 구후마취로 인하여 이 반응의 구심로가 차단된 것으로 볼 수 있다.

[영문]

The purpose of the present study is to find out whether the ophthalmotonic

consensual reaction really exists and through what channel the reaction is brought

about in rabbits.

Twenty-eight pigmented male rabbits were divided into four groups of seven

rabbits each, and the intraocular pressure of each eye was measured at designated

times in each group with a Mueller electronic tonometer under topical anesthesia

(0.5% tetracaine hydrochloride).

Retrobulbar anesthesia and compression were performed in each group as follows:

Group ①: From 56 minutes to 60 minutes after the experiment had begun, the right

eye was compressed for 4 minutes with a 50 gm. weight by means of a Baillart

ophthalomodynamometer.

Group ②: About one hour after the experiment had begun, 1.0cc. of 2% procaine

hydrochloride was given by retrobulbar injection on the right side. Digital message

after retrobulbar injection was avoided and epinephrine was not employed, because

they might influence the intraocular pressure.

Group ③: After retrobulbar anesthesia had been performed for the right eye at 40

minutes, this eye was compressed by the above described method from 86 minutes to

90 minutes after the experiment had begun.

Group ④: After retrobulbar anesthesia had been performed in the left eye at 40

minutes, the right eye was compressed by the above described method from 86 minutes

to 90 minutes after the experiment had begun.

The data of each experimental group were analyzed statistically by means of the

t-test.

Four group of tonometric studies were done with the following results:

1. After the right eye had been compressed with a 50 gm. wieght for 4 minutes,

the right intraocular pressure was found to be lowered and then immediately

elevated.

The intraocular pressure in the left eye was lowered beginning about 20 minutes

after the right eye compression, and this phenomenon may be considered as the

ophthalmotonic consensual reaction.

2. After retrobulbar anesthesia with 1.0cc. of 2% procaine hydrochloride had been

performed for the right eye, the intraocular pressure was found to be lowered, but

that of the left eye showed a slight rise and maintenance of the elevated pressure.

3. when the right eye was compressed after retrobulbar anesthesia had been

performed, the grade of rising of the intraocular pressure was lower than when

retrobulbar anesthesia had not been performed. The intraocular pressure in the left

eye showed no significant change, so it can be postulated that the afferent pathway

of the ophthalmotonic consensual reaction was blocked by the retrobulbar anesthesia

in the compressed right eye.

4. When the right eye was compressed after retrobulbar anesthesia had been

performed previously in the left eye, the change of the intraocular pressure in the

right eye, the change of the intraocular pressure in the right eye showed no

difference as when retrobulbar anesthesia had not been performed in the left eye.

the intraocular pressure in the left eye showed a similar change as when the right

eye had not been compressed, so it can be postulated that the efferent pathway of

the ophthalmotonic consensual reaction was blocked by the retrobulbar anesthesia in

the non-compressed left eye.