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Health Surveillance of Specific Pathogen-Free and Conventionally-Housed Mice and Rats in Korea

Authors
 Seunghyeok SEOK  ;  Jonghwan PARK  ;  Jaehak PARK  ;  Kitaek NAM  ;  Beomseok HAN  ;  Dongdeuk JANG  ;  Kihwa YANG  ;  Dongjae KIM  ;  Huiyoung LEE  ;  Minwon BAEK  ;  Suna CHO 
Citation
 EXPERIMENTAL ANIMALS, Vol.54(1) : 85-92, 2005 
Journal Title
EXPERIMENTAL ANIMALS
ISSN
 1341-1357 
Issue Date
2005
MeSH
Animals ; Animals, Laboratory/microbiology* ; Animals, Laboratory/parasitology ; Animals, Laboratory/virology ; Cryptosporidium/isolation & purification ; Enzyme-Linked Immunosorbent Assay ; Helicobacter/isolation & purification ; Housing, Animal ; Korea ; Mice ; Mice, Inbred Strains/microbiology* ; Mice, Inbred Strains/parasitology ; Mice, Inbred Strains/virology ; Murine hepatitis virus/isolation & purification ; Mycoplasma/isolation & purification ; Polymerase Chain Reaction ; Quarantine/standards ; Rats ; Rats, Inbred Strains/microbiology* ; Rats, Inbred Strains/parasitology ; Rats, Inbred Strains/virology ; Sendai virus/isolation & purification ; Specific Pathogen-Free Organisms*
Keywords
15725684
Abstract
The present study contains information about proper microbiological monitoring of laboratory animals' health and the standardization of microbiological monitoring methods in Korea. Microbiological quality control for laboratory animals, composed of biosecurity and health surveillance, is essential to guard against research complications and public health dangers that have been associated with adventitious infections. In this study, one hundred and twenty-two mice and ninety rats from laboratory animal breeding companies and one animal facility of the national universities in Korea were monitored in 2000-2003. Histopathologically, thickening of the alveolar walls and lymphocytic infiltration around the bronchioles were observed in mice and rats from microbiologically contaminated facilities. Cryptosporidial oocysts were observed in the gastric pits of only conventionally-housed mice and rats. Helicobacter spp. infection was also detected in 1 of 24 feces DNA samples in mice and 9 of 40 feces DNA samples in rats by PCR in 2003, but they were not Helicobacter hepaticus. This paper describes bacteriological, parasitological, and virological examinations of the animals.
Files in This Item:
T200505092.pdf Download
DOI
OAK-2005-02271
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114990
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