Cited 170 times in
Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이향규 | - |
dc.date.accessioned | 2015-08-26T16:43:37Z | - |
dc.date.available | 2015-08-26T16:43:37Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114978 | - |
dc.description.abstract | Drosophila peptidoglycan recognition protein LC (PGRP-LC), a transmembrane protein required for the response to bacterial infection, acts at the top of a cytoplasmic signaling cascade that requires the death-domain protein Imd and an IκB kinase to activate Relish, an NF-κB family member. It is not clear how binding of peptidoglycan to the extracellular domain of PGRP-LC activates intracellular signaling because its cytoplasmic domain has no homology to characterized proteins. Here, we demonstrate that PGRP-LC binds Imd and that its cytoplasmic domain is critical for its activity, suggesting that PGRP-LC acts as a signal-transducing receptor. The PGRP-LC cytoplasmic domain is also essential for the formation of dimers, and results suggest that dimerization may be required for receptor activation. The PGRP-LC cytoplasmic domain can mediate formation of heterodimers between different PGRP-LC isoforms, thereby potentially expanding the diversity of ligands that can be recognized by the receptor. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1122~1126 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Carrier Proteins/chemistry | - |
dc.subject.MESH | Carrier Proteins/physiology* | - |
dc.subject.MESH | Dimerization | - |
dc.subject.MESH | Drosophila/immunology* | - |
dc.subject.MESH | Drosophila Proteins/chemistry | - |
dc.subject.MESH | Drosophila Proteins/physiology | - |
dc.subject.MESH | Immunity, Innate* | - |
dc.subject.MESH | Signal Transduction* | - |
dc.title | Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor | - |
dc.type | Article | - |
dc.contributor.college | College of Nursing (간호대학) | - |
dc.contributor.department | Dept. of Nursing Environment Systems (임상간호과학과) | - |
dc.contributor.googleauthor | Kwang-Min Choe | - |
dc.contributor.googleauthor | Hyangkyu Lee | - |
dc.contributor.googleauthor | Kathryn V. Anderson | - |
dc.identifier.doi | 10.1073/pnas.0404952102 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03282 | - |
dc.relation.journalcode | J02550 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.pmid | 15657141 | - |
dc.subject.keyword | Imd | - |
dc.subject.keyword | innate immunity | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | Relish | - |
dc.contributor.alternativeName | Lee, Hyang Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Hyang Kyu | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 102 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1122 | - |
dc.citation.endPage | 1126 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.102(4) : 1122-1126, 2005 | - |
dc.identifier.rimsid | 39356 | - |
dc.type.rims | ART | - |
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