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Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear

DC Field Value Language
dc.contributor.author복진웅-
dc.date.accessioned2015-08-26T16:42:52Z-
dc.date.available2015-08-26T16:42:52Z-
dc.date.issued2005-
dc.identifier.issn0950-1991-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/114956-
dc.description.abstractAn early and crucial event in vertebrate inner ear development is the acquisition of axial identities that in turn dictate the positions of all subsequent inner ear components. Here, we focus on the role of the hindbrain in establishment of inner ear axes and show that axial specification occurs well after otic placode formation in chicken. Anteroposterior (AP) rotation of the hindbrain prior to specification of this axis does not affect the normal AP orientation and morphogenesis of the inner ear. By contrast, reversing the dorsoventral (DV) axis of the hindbrain results in changing the DV axial identity of the inner ear. Expression patterns of several ventrally expressed otic genes such as NeuroD, Lunatic fringe (Lfng) and Six1 are shifted dorsally, whereas the expression pattern of a normally dorsal-specific gene, Gbx2, is abolished. Removing the source of Sonic Hedgehog (SHH) by ablating the floor plate and/or notochord, or inhibiting SHH function using an antibody that blocks SHH bioactivity results in loss of ventral inner ear structures. Our results indicate that SHH, together with other signals from the hindbrain, are important for patterning the ventral axis of the inner ear. Taken together, our studies suggest that tissue(s) other than the hindbrain confer AP axial information whereas signals from the hindbrain are necessary and sufficient for the DV axial patterning of the inner ear.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2115~2124-
dc.relation.isPartOfDEVELOPMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHChick Embryo-
dc.subject.MESHEar, Inner/embryology*-
dc.subject.MESHEar, Inner/physiology-
dc.subject.MESHEmbryonic Induction/physiology*-
dc.subject.MESHHedgehog Proteins-
dc.subject.MESHNotochord/metabolism-
dc.subject.MESHRhombencephalon/physiology*-
dc.subject.MESHTrans-Activators/physiology-
dc.titleRole of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학)-
dc.contributor.googleauthorJinwoong Bok-
dc.contributor.googleauthorMarianne Bronner-Fraser-
dc.contributor.googleauthorDoris K. Wu-
dc.identifier.doi10.1242/dev.01796-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01865-
dc.relation.journalcodeJ00710-
dc.identifier.eissn1477-9129-
dc.identifier.pmid15788455-
dc.subject.keywordInner ear-
dc.subject.keywordAxis-
dc.subject.keywordAxial specification-
dc.subject.keywordInduction-
dc.subject.keywordHindbrain-
dc.subject.keywordRhombomere-
dc.subject.keywordSonic hedgehog-
dc.subject.keywordSHH-
dc.subject.keywordChicken-
dc.contributor.alternativeNameBok, Jin Woong-
dc.contributor.affiliatedAuthorBok, Jin Woong-
dc.rights.accessRightsfree-
dc.citation.volume132-
dc.citation.number9-
dc.citation.startPage2115-
dc.citation.endPage2124-
dc.identifier.bibliographicCitationDEVELOPMENT, Vol.132(9) : 2115-2124, 2005-
dc.identifier.rimsid39338-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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