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누드마우스에서 골 형성에 대한 BMP와 PDGF 복합사용의 효과

Other Titles
 Effect of the combined use of bone morphogenetic protein and platelet-derived growth factor on bone formation in nude mouse 
Authors
 최병호  ;  주석강  ;  이승호  ;  허진영  ;  정재형  ;  김병용 
Citation
 Journal of Korean Academy of Periodontology (대한치주과학회지), Vol.35(2) : 263-269, 2005 
Journal Title
Journal of Korean Academy of Periodontology(대한치주과학회지)
ISSN
 2093-2278 
Issue Date
2005
MeSH
BMP ; PDGF ; growth factor ; bone formation
Keywords
BMP ; PDGF ; growth factor ; bone formation
Abstract
Bone morphogenetic protein(BMP) and platelet-derived growth factor(PDGF) have been demonstrated tostimulate bone formation when applied locally in vivo. To explore whether or not the combined use of BMP and PDGF could have promotive effect and synergic interac- tion on bone formation in vivo, bone marrow mesenchymal stem cells were treated with BMP-2, PDGF-BB, or BMP-2 plus PDGF-BB, and then these cells were injected into the subcutaneous space on the dorsum of nude mice. The bone formation was evaluated after 12 weeks. Histomorphometric analysis demonstrated that the subcutaneous nodules formed in nude mice contained 25.3% newly formed bone in the BMP-2 treated cells, 14.4% newly formed bone in the PDGF-BB treated cells, and 8.9% newly formed bone in the BMP-2 plus PDGF-BB treated cells. The results showed that the combination of BMP-2 and PDGF-BB had neither a promotive effect nor synergic interact on bone formation in vivo.
Files in This Item:
T200504418.pdf Download
DOI
OAK-2005-02187
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Byung Yong(김병용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114942
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