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Diagnostic performance of F-18-FDG PET and ictal Tc-99m-HMPAO SPET in pediatric temporal lobe epilepsy: Quantitative analysis by statistical parametric mapping, statistical probabilistic anatomical map, and subtaction ictal SPET

Authors
 Jong Jin Lee  ;  Won Jun Kang  ;  Myung Chul Lee  ;  June-Key Chung  ;  Yong-Seung Hwang  ;  Ki Joong Kim  ;  Hee Hwang  ;  Jae Sung Lee  ;  Dong Soo Lee 
Citation
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol.14(3) : 213-220, 2005 
Journal Title
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
ISSN
 1059-1311 
Issue Date
2005
MeSH
Pediatric ; Temporal lobe ; epilepsy ; PET ; SPET ; SPM ; SPAM ; SISCOM
Keywords
Pediatric ; Temporal lobe ; epilepsy ; PET ; SPET ; SPM ; SPAM ; SISCOM
Abstract
We investigated the diagnostic performance of 18F-FDG PET and ictal 99mTc-HMPAO SPET in pediatric temporal lobe epilepsy (TLE). Twenty-one pediatric TLE patients were enrolled in this study. Their diagnoses were confirmed by histology and post-surgical outcome (Engel class I or II). The patients’ ages were 18 or younger (15 ± 3 years). Of the 21 patients, 21 patients underwent 18F-FDG PET scan and 15 underwent ictal 99mTc-HMPAO SPET. Preoperative PET and/or ictal SPET images were reviewed by simple visual assessment and by statistical parametric mapping (SPM). Asymmetric indices (AI) were calculated using statistical probabilistic anatomical map (SPAM) on 18F-FDG PET. In nine patients who underwent both ictal and interictal SPET, SISCOM (subtraction ictal SPET coregistered to MR template) was performed. PET correctly localized epileptogenic zones in 20 of 21 (95%) by visual assessment. SPM analysis of PET correctly localized epileptogenic zones in 18 of 21 (86%). Ictal SPET correctly localized epileptogenic zones in 12 of 15 (80%) by visual assessment. SPM analysis of ictal SPET correctly localized epileptogenic zones in 12 of 15 (80%). SISCOM correctly localized 8 of 9 (89%), which was equal to that of visual assessment of ictal SPET. The AIs of the temporal lobes by PET were −15 ± 8.4 in the left and 9.9 ± 8.9 in the right TLE (normal control: −2.9 ± 2.8), and correctly localized epileptogenic zones in all cases. As is found in adult TLE, PET and ictal SPET efficiently localized epileptogenic zones in pediatric TLE. SPM analysis of PET or ictal SPET could be used as an aid to visual assessment. Moreover, SISCOM was equal visual assessment of ictal SPET images in terms of lesion localizations.
Files in This Item:
T200504246.pdf Download
DOI
10.1016/j.seizure.2005.01.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Jun(강원준) ORCID logo https://orcid.org/0000-0002-2107-8160
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114936
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