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Combined Treatment of an Intratumoral Injection of Dendritic Cells and Systemic Chemotherapy (Paclitaxel) for Murine Fibrosarcoma

Authors
 Gwang-Seong Choi  ;  Moon-Hee Lee  ;  Sun U. Song  ;  Min-Geol Lee  ;  Woo-Chul Kim  ;  Jong-Rok Lee  ;  Do-Hwan Seong  ;  Hye-Yun Kil  ;  Moon-Whan Im  ;  Hong-Sik Lee  ;  Chul-Soo Kim  ;  Soon-Ki Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.46(6) : 835-842, 2005 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2005
MeSH
Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/therapeutic use* ; Bone Marrow Cells/cytology ; Cell Line, Tumor ; Cells, Cultured ; Combined Modality Therapy ; Dendritic Cells/cytology ; Dendritic Cells/transplantation* ; Fibrosarcoma/drug therapy ; Fibrosarcoma/pathology ; Fibrosarcoma/therapy* ; Immunologic Memory ; Injections, Intraperitoneal ; Mice ; Paclitaxel/administration & dosage ; Paclitaxel/therapeutic use* ; Phenotype ; Transplantation, Isogeneic ; Treatment Outcome
Keywords
Dendritic cells ; paclitaxel ; immunotherapy
Abstract
A novel combined treatment of conventional chemotherapy with an intratumoral injection of syngeneic dendritic cells (DCs) has emerged as a potent cancer treatment strategy. In this study, we evaluated the synergistic effect of an intraperitoneal (i.p.) injection of a chemotherapeutic drug, paclitaxel, and an intratumoral (i.t.) injection of syngeneic bone marrow-derived DCs for the treatment of pre-existing fibrosarcoma. Subcutaneous tumors were established using MCA102 fibrosarcoma cells in syngeneic C57BL/6 mice. The results demonstrated that the combined treatment of paclitaxel chemotherapy and the injection of DCs led to complete tumor regression, in contrast to only partial eradication of the tumors with chemotherapy or DCs alone. Furthermore, the tumor-free mice were able to resist a repeat challenge with the same type of tumor. These findings suggest that a combination therapy of systemic chemotherapy along with the intratumoral administration of DCs is a potent treatment strategy for fibrosarcoma.
Files in This Item:
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DOI
10.3349/ymj.2005.46.6.835
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
Lee, Hong Shick(이홍식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114929
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