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TNF-α 길항제 투여로 관해가 유도된 불응성 성인형 스틸병

Other Titles
 Refractory Cases of Adult Onset Still's Disease Successfully Treated with TNF-α Blocker 
Authors
 박인혜  ;  박민찬  ;  이수곤  ;  박용범  ;  최상태 
Citation
 Journal of the Korean Rheumatism Association (대한류마티스학회지), Vol.12(4) : 335-340, 2005 
Journal Title
 Journal of the Korean Rheumatism Association  (대한류마티스학회지) 
ISSN
 1226-8070 
Issue Date
2005
Abstract
Adult onset Still`s disease (AOSD) is a systemic inflammatory disorder of unknown etiology characterized by spiking fever, evanescent salmon-colored rash, polyarthritis and leukocytosis. The diagnosis of AOSD remains a challenge to clinicians and requires a high index of suspicion because of its rarity and nonspecific symptoms. Although the etiology and pathogenesis of AOSD is not elucidated clearly, the pathogenetic role of inflammatory cytokines, such as interleukin (IL)-6, IL-8, IL-18 and tumor necrosis factor (TNF)-α were suggested and the correlations of their levels with disease activity were also reported. These results raise a possibility that the blocking of these cytokines may provide a therapeutic benefit in controlling disease activity and relieving the symptoms of AOSD. Recently, we experienced two cases of AOSD, who were refractory to the treatment with high dose glucocorticoid and immunosuppressive agents. Both were treated with TNF- blockers and experienced remissions thereafter. These experiences might support the use of biologic agents in refractory AOSD.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
박민찬(Park, Min Chan) ORCID logo https://orcid.org/0000-0003-1189-7637
박용범(Park, Yong Beom)
박인혜(Park, In Hae)
이수곤(Lee, Soo Kon)
최상태(Choi, Sang Tae)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114902
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