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Helicobacter pylori 일,이차 제균요법 실패 후 Moxifloxacin 포함 삼제병합요법 시도

Other Titles
 Trial of Moxifloxacin-containing Triple Therapy after Initial and Second-line Treatment Failures for Helicobacter pylori Infection 
Authors
 천재희  ;  김나영  ;  송인성  ;  정현채  ;  서승오  ;  김정목  ;  박영수  ;  황진혁  ;  김진욱  ;  이동호 
Citation
 Korean Journal of Gastroenterology, Vol.45(2) : 111-117, 2005 
Journal Title
Korean Journal of Gastroenterology(대한소화기학회지)
ISSN
 1598-9992 
Issue Date
2005
MeSH
Helicobacter pylori ; Second-line therapy ; Rescue therapy ; Moxifloxacin
Keywords
Helicobacter pylori ; Second-line therapy ; Rescue therapy ; Moxifloxacin
Abstract
Background/Aims: Proton-pump inhibitor (PPI)-based triple therapy for Helicobacter pylori eradication is widely used with considerable failure rate. Bismuth-based, second-line therapy is also associated with failures in more than 20% of cases in Korea. Our aim was to evaluate the efficacy and tolerability of third-line therapy containing moxifloxacin as a rescue in Korea.

Methods: The subjects consisted of 201 patients nfected with H. pylori, who were treated with PPI-based therapy, 42 patients treated with bismuth-based after failure of initial PPI triple therapy, and 10 patients treated with moxifloxacin-containing triple therapy after failure of successive initial and second-line therapy. Eradication rate, compliance and side effect rates were compared.

Results:The eradication rates of initial, second-line, and third-line therapy were as follows: 67.2%/83.3%, 54.8%/76.7%, 80.0%/88.9% by intention-to-treat and per protocol analysis, respectively. The compliance of patients for each treatment was 98.2%, 90.9%, 100%, respectively. The side effect rate was significantly higher in the bismuth riple therapy than in the PPI- or moxifloxacin-containing triple therapy (p<0.05).

Conclusions: Moxifloxacin-containing triple therapy shows high eradication rate with fewer side effects and good compliance. Thus, this regimen could be used as a rescue therapy.
Files in This Item:
T200503605.pdf Download
DOI
OAK-2005-02088
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114880
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